All AbMole products are for research use only, cannot be used for human consumption.
DRI-C21045 is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM.
DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively. DRI-C21045 (0.4-50 μM; 48 h) inhibits CD40L-induced MHC-II upregulation in THP-1 cells.
DRI-C21045 (30 mg/kg; s.c.; daily) prolongs graft survival in a murine allogeneic skin transplant model.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Full-thickness ear skins from BALB/c were transplanted onto the dorsal thorax of C57BL/6 |
| Formulation | in 20% w/v hydroxypropyl-β-cyclodextrin (HPβCD) solution |
| Dosages | 30 mg/kg |
| Administration | daily, s.c. |
| Molecular Weight | 580.61 |
| Formula | C32H24N2O7S |
| CAS Number | 2101765-81-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 2 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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