Certificate of Analysis

 

Product Name: DRI-C21045
Catalog Number: M25496
CAS Number: 2101765-81-3

Physical and Chemical Properties
Formula: C32H24N2O7S
Molecular Weight: 580.61
Form: Solid
Solubility: DMSO 2 mg/mL (Need ultrasonic)
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: DRI-C21045 Structure
Analytical Data
QC Standard: >98.0%
H-NMR: Consistent with structure
Product Information
Description: DRI-C21045 is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.