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Mitazalimab

Cat. No. M24893

All AbMole products are for research use only, cannot be used for human consumption.

Mitazalimab Structure
Synonym:

ADC-1013; JNJ-64457107

Size Price Availability
1mg USD 280  USD280 3-4 Weeks
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Quality Control & Documentation
Biological Activity

Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment.

Chemical Information
CAS Number 2055640-86-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Adnan Deronic, et al. Cancer Immunol Immunother. The human anti-CD40 agonist antibody mitazalimab (ADC-1013; JNJ-64457107) activates antigen-presenting cells, improves expansion of antigen-specific T cells, and enhances anti-tumor efficacy of a model cancer vaccine in vivo

[2] Sandra M M Irenaeus, et al. Int J Cancer. First-in-human study with intratumoral administration of a CD40 agonistic antibody, ADC-1013, in advanced solid malignancies

[3] Roxana S Dronca, et al. Clin Cancer Res. Immunomodulatory antibody therapy of cancer: the closer, the better

[4] Sara M Mangsbo, et al. Clin Cancer Res. The human agonistic CD40 antibody ADC-1013 eradicates bladder tumors and generates T-cell-dependent tumor immunity

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Abmole Inhibitor Catalog




Keywords: Mitazalimab, ADC-1013; JNJ-64457107 supplier, TNF Receptor, inhibitors, activators

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