| Cat.No. | Name | Information |
|---|---|---|
| M1962 | Lenalidomide | Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. |
| M6224 | Etanercept | Etanercept is a dimer fusion protein that binds tumor necrosis factor (TNF) as a TNF inhibitor. Etanercept competitively inhibits the binding of TNF-α and TNF-β to TNF receptors on the cell surface, rendering tumor necrosis factor biologically inactive. |
| M41378 | TNF-α-IN-11 | TNF-α-IN-11 is a TNF-α inhibitor with a KD value of 12.06 μM. |
| M41377 | WP9QY | WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. |
| M41376 | DRI-C21041 | DRI-C21041 is a CD40/CD40L interaction inhibitor, with an IC50 of 0.31 μM. |
| M41375 | DRI-C25441 | DRI-C25441 is a potent blocker of CD40 and CD40L interaction, with an IC50 of 0.36 μM. |
| M41374 | Gnetifolin E | Gnetifolin E is a resveratrol trimer derivative that can be isolated from Gnetum brunonianum. |
| M41373 | Immuno modulator-1 | Immuno modulator-1 inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. |
| M38858 | Undecane | Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[ |
| M38857 | Episappanol | Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and TNF-α secretion. |
| M31423 | SAR441566 | SAR441566 is an orally active TNF-α inhibitor that blocks the interaction of TNFα with TNFR1 by distorting the conformation of the soluble TNFα trimer and does not affect signaling of TNFα bound to cell membranes, and can be used in rheumatoid arthritis-related studies. |
| M31422 | IA-14069 | IA-14069 is an orally active TNF-α inhibitor for studies related to rheumatoid arthritis. |
| M31421 | Isomyosmine | Isomyosmine is an orally active inhibitor of TNF-alpha that can be used in studies related to sarcopenia as well as chronic inflammation. |
| M30316 | Hispidol | Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM. |
| M30105 | HDMAPP triammonium | HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α). |
| M30086 | SMI 6860766 | SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation. |
| M30032 | IW927 | IW927 is a potent small molecule antagonist that blocks the binding of TNF-α to TNFRc1 with an IC50 value of 50 nM and disrupts TNFα-induced IκB phosphorylation with an IC50 value of 600 nM. |
| M29272 | GW-3333 | GW-3333 is a potent and orally active TNF-alpha-converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitor. GW-3333 inhibits tumor necrosis factor-alpha (TNF-alpha) production and arthritis. |
| M29166 | TNF-α-IN-2 | TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα), with an IC50 of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis. |
| M28790 | cis-Mulberroside A | cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM. |
| M27716 | SPD304 dihydrochloride | SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α. |
| M25497 | (Rac)-BIO8898 | (Rac)-BIO8898 is a CD40-CD154 co-stimulatory interaction inhibitor. (Rac)-BIO8898 inhibits CD154 binding to CD40-Ig with an IC50 of 25 μM. |
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