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STAR-0310 is a novel OX40 antagonistic monoclonal antibody which has a potential best-in-class profile with a high affinity, potential for favorable safety and tolerability profile with low T cell depletion from ADCC or possible on-target cellular toxicity. STAR-0310 is a novel, affinity-matured YTE-modified (M252Y/S254T/T256E) monoclonal antibody that inhibits the OX40 receptor. STAR-0310 targets the OX40 pathway, impacting Th1, Th2 and Th17/22 pathways and preserving the regulatory T cells. STAR-0310 showed less activated T cell depletion compared to rocatinlimab, which demonstrated a 5-fold greater killing capacity; STAR-0310 showed ~75% less maximal killing on activated T cells relative to rocatinlimab.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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