| Cat.No. | Name | Information |
|---|---|---|
| M1962 | Lenalidomide | Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. |
| M6224 | Etanercept | Etanercept is a dimer fusion protein that binds tumor necrosis factor (TNF) as a TNF inhibitor. Etanercept competitively inhibits the binding of TNF-α and TNF-β to TNF receptors on the cell surface, rendering tumor necrosis factor biologically inactive. |
| M53366 | Delmitide | Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. |
| M49437 | PF-06480605 | PF-06480605 is an IgG1 human monoclonal antibody against TNF-like ligand 1A (TL1A, TNFSF15), which can be used in studies related to ulcerative colitis (UC). |
| M49436 | V565 | V565 is a novel antibody that specifically targets TNFα and can be used in studies related to Crohn's disease (CD). |
| M45266 | Linvoseltamab | Linvoseltamab is a bispecific antibody targeting BCMA (TNFRSF17) and CD3. Linvoseltamab is used in studies related to relapsed/refractory multiple myeloma (R/R MM). |
| M45222 | TEV’574 | TEV'574 is a TL1A antibody with a unique binding epitope that blocks TL1A binding to the DR3 receptor without affecting TL1A binding to the DcR3 pseudoreceptor. It can be used in studies related to ulcerative colitis and Crohn's disease. |
| M44749 | 5-Hydroxy-3',4',7-trimethoxyflavone | 7,3',4'-Tri-O-methylluteolin possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. |
| M43929 | Zigakibart | Zigakibart is an anti-APRIL monoclonal antibody that can be used in studies related to IgA nephropathy (IgAN). |
| M41608 | Fisetin quarterhydrate | Fisetin quarterhydrate is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects. |
| M41379 | BMS-561392 formate | BMS-561392 formate is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease. |
| M41378 | TNF-α-IN-11 | TNF-α-IN-11 is a TNF-α inhibitor with a KD value of 12.06 μM. |
| M41377 | WP9QY | WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. |
| M41376 | DRI-C21041 | DRI-C21041 is a CD40/CD40L interaction inhibitor, with an IC50 of 0.31 μM. |
| M41375 | DRI-C25441 | DRI-C25441 is a potent blocker of CD40 and CD40L interaction, with an IC50 of 0.36 μM. |
| M41374 | Gnetifolin E | Gnetifolin E is a resveratrol trimer derivative that can be isolated from Gnetum brunonianum. |
| M41373 | Immuno modulator-1 | Immuno modulator-1 inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. |
| M38858 | Undecane | Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[ |
| M38857 | Episappanol | Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and TNF-α secretion. |
| M31422 | IA-14069 | IA-14069 is an orally active TNF-α inhibitor for studies related to rheumatoid arthritis. |
| M31421 | Isomyosmine | Isomyosmine is an orally active inhibitor of TNF-alpha that can be used in studies related to sarcopenia as well as chronic inflammation. |
| M30316 | Hispidol | Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM. |
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