Microtubule Microtubule

Cat.No.	Name	Information
M1970	Paclitaxel	Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM.
M3912	Vinblastine sulfate	Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase.
M1940	Docetaxel	Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity.
M9818	Auristatin E	Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity.
M9541	DM4	DM4, a chemical derivative of maytansine, is a potent and selective cytotoxic agent that inhibit cell division.
M9216	VcMMAE	VcMMAE is an anti-mitotic compound, monomethylauristatin E (MMAE), linked by a lysosomal cleavable dipeptide, valine-citrulline (VC). *The compound is unstable in solutions, freshly prepared is recommended
M9010	Crolibulin	Crolibulin (also known as EPC2407 and crinobulin) is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity.
M8967	Maytansinol	Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent.
M6535	BTB-1	BTB-1 is a selective and ATP-competitive Kif18A inhibitor, with IC50 value of 1.69 μM.
M6292	Ansamitocin P 3	Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic.
M6278	Epothilone D	Epothilone D is a potent microtubule stabilizer.
M5626	Estramustine phosphate sodium	Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
M5588	Docetaxel Trihydrate	Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
M5392	Albendazole Oxide	Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
M5296	PE859	PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively.
M5282	INH6	INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
M5222	Mertansine	Mertansine is a tubulin inhibitor，inhibits the assembly of microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). *The compound is unstable in solutions, freshly prepared is recommended
M5068	ELR510444	ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines.
M5042	MMAD	Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody compound conjugate.
M5041	MMAF	Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody compound cytotoxin.*The compound is unstable in solutions, freshly prepared is recommended
M5039	10-Deacetyl-7-xylosyl paclitaxel	10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility.
M4975	Cevipabulin	Cevipabulin (TTI-237) is a novel, potent, oral, microtubule-active antitumor small molecule, inhibits the binding of [3H] vinblastine to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line.
M4857	Epothilone B	Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.

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