| Cat.No. | Name | Information |
|---|---|---|
| M1970 | Paclitaxel | Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. |
| M3912 | Vinblastine sulfate | Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase. |
| M1940 | Docetaxel | Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. |
| M10491 | Batabulin sodium | Batabulin (T138067) sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity, covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis. |
| M10393 | Eribulin mesylate | Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer. |
| M9818 | Auristatin E | Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. |
| M9541 | DM4 | DM4, a chemical derivative of maytansine, is a potent and selective cytotoxic agent that inhibit cell division. |
| M9216 | VcMMAE | VcMMAE is an anti-mitotic compound, monomethylauristatin E (MMAE), linked by a lysosomal cleavable dipeptide, valine-citrulline (VC). *The compound is unstable in solutions, freshly prepared is recommended |
| M9010 | Crolibulin | Crolibulin (also known as EPC2407 and crinobulin) is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. |
| M8967 | Maytansinol | Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent. |
| M6535 | BTB-1 | BTB-1 is a selective and ATP-competitive Kif18A inhibitor, with IC50 value of 1.69 μM. |
| M6292 | Ansamitocin P 3 | Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic. |
| M6278 | Epothilone D | Epothilone D is a potent microtubule stabilizer. |
| M5626 | Estramustine phosphate sodium | Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. |
| M5588 | Docetaxel Trihydrate | Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. |
| M5392 | Albendazole Oxide | Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations. |
| M5296 | PE859 | PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. |
| M5282 | INH6 | INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. |
| M5222 | Mertansine | Mertansine is a tubulin inhibitor，inhibits the assembly of microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). *The compound is unstable in solutions, freshly prepared is recommended |
| M5068 | ELR510444 | ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines. |
| M5042 | MMAD | Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody compound conjugate. |
| M5041 | MMAF | Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody compound cytotoxin.*The compound is unstable in solutions, freshly prepared is recommended |
| M5039 | 10-Deacetyl-7-xylosyl paclitaxel | 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility. |
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