| Cat.No. | Name | Information |
|---|---|---|
| M1970 | Paclitaxel | Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. |
| M3912 | Vinblastine sulfate | Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase. |
| M1940 | Docetaxel | Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. |
| M9010 | Crolibulin | Crolibulin (also known as EPC2407 and crinobulin) is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. |
| M8967 | Maytansinol | Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent. |
| M6535 | BTB-1 | BTB-1 is a selective and ATP-competitive Kif18A inhibitor, with IC50 value of 1.69 μM. |
| M6292 | Ansamitocin P 3 | Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic. |
| M6278 | Epothilone D | Epothilone D is a potent microtubule stabilizer. |
| M5626 | Estramustine phosphate sodium | Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. |
| M5588 | Docetaxel Trihydrate | Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. |
| M5392 | Albendazole Oxide | Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations. |
| M5296 | PE859 | PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. |
| M5282 | INH6 | INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. |
| M5222 | Mertansine | Mertansine is a tubulin inhibitor，inhibits the assembly of microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). *The compound is unstable in solutions, freshly prepared is recommended |
| M5068 | ELR510444 | ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines. |
| M5042 | MMAD | Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody compound conjugate. |
| M5041 | MMAF | Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody compound cytotoxin.*The compound is unstable in solutions, freshly prepared is recommended |
| M5039 | 10-Deacetyl-7-xylosyl paclitaxel | 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility. |
| M4975 | Cevipabulin | Cevipabulin(TTI-237) is a novel, potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer. |
| M4857 | Epothilone B | Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. |
| M4780 | 4-Demethylepipodophyllotoxin | 4 '- Demethylepipodophyllotoxin (4' - DMEP) is an intermediate compounds, can inhibit microtubule assembly. |
| M4417 | 7-Epitaxol | 7-Epi-Taxol is the active metabolite of Taxol, which has similar effects to Taxol in inhibiting cell proliferation, microtubule dissociation and inducing microtubule polymerization. |
| M4416 | Cephalomannine | Cephalomannine is a taxol alkaloid analogue that can be isolated from most tricuspid taxus species. Cephalomannine is an orally active anti-tumor agent that can be used as a chemotherapy agent for cancer research. |
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