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DM4

Cat. No. M9541
DM4 Structure
Synonym:

Maytansinoid DM4

Size Price Availability Quantity
5mg USD 345  USD345 In stock
10mg USD 535  USD535 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

DM4 has anticancer properties of maytansinoids due to their ability to disrupt microtubule function. Maytansinoid DM4 can be use to make antibody drug conjugates such as Anetumab ravtansine (BAY 94-9343) and Indatuximab ravtansine (BT062). Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 780.37
Formula C38H54ClN3O10S
CAS Number 796073-69-3
Purity >98%
Solubility DMSO ≥ 70 mg/mL
Storage at -20°C
References

[1] Zhao XY, et al. Clin Cancer Drv gs. Novel Antibody Therapeutics Targeting Mesothelin In Solid Tumors.

[2] Ruoping Tang, et al. BMC Cancer. P-gp Activity Is a Critical Resistance Factor Against AVE9633 and DM4 Cytotoxicity in Leukaemia Cell Lines, but Not a Major Mechanism of Chemoresistance in Cells From Acute Myeloid Leukaemia P atl ents.

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Keywords: DM4, Maytansinoid DM4 supplier, Microtubule, inhibitors

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