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Microtubule Microtubule

Cat.No.  Name Information
M3912 Vinblastine sulfate Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase.
M1970 Paclitaxel Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM.
M1940 Docetaxel Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity.
M43814 WAY-118959-A WAY-118959-A is a potential microtubule acetylation inhibitor.
M30435 Bis-ANS dipotassium  Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations.
M29256 Davunetide  Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity.
M27799 Dolastatin 10 Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.
M22468 Sovilnesib (AMG 650) Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 μM.
M22255 Eribulin Eribulin
M20601 TAI-1 TAI-1 is a first-in-class, potent, specific, orally active Hec1 inhibitor that disrupts the Hec1-Nek2 protein interaction.
M13692 MMAF hydrochloride MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent.
M13690 MMAE-d8 D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
M13689 Cevipabulin fumarate Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line.
M10750 BNC105 BNC105 IS A TUBULIN POLYMERIZATION INHIBITOR THAT IS RESISTANT TO PROLIFERATION AND DESTRUCTION OF TUMOR VASCULAR FUNCTION.
M10749 Verubulin Verubulin (MPC-6827) is a highly effective, broad-spectrum microtubule blocker with in vivo and in vitro cytotoxic activity, promising as a potential drug candidate for a wide range of cancers.
M10491 Batabulin sodium Batabulin (T138067) sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity, covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis.
M10393 Eribulin mesylate Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer.
M9818 Auristatin E Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity.
M9541 DM4 DM4, a chemical derivative of maytansine, is a potent and selective cytotoxic agent that inhibit cell division.
M9216 VcMMAE VcMMAE is an anti-mitotic compound, monomethylauristatin E (MMAE), linked by a lysosomal cleavable dipeptide, valine-citrulline (VC). *The compound is unstable in solutions, freshly prepared is recommended




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