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Microtubule Microtubule

Cat.No.  Name Information
M3912 Vinblastine sulfate Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase.
M1970 Paclitaxel Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM.
M1940 Docetaxel Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity.
M27799 Dolastatin 10 Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.
M22468 Sovilnesib (AMG 650) Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 μM.
M13692 MMAF hydrochloride MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent.
M13690 MMAE-d8 D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
M13689 Cevipabulin fumarate Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line.
M10749 Verubulin Verubulin (MPC-6827) is a highly effective, broad-spectrum microtubule blocker with in vivo and in vitro cytotoxic activity, promising as a potential drug candidate for a wide range of cancers.
M10491 Batabulin sodium Batabulin (T138067) sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity, covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis.
M10393 Eribulin mesylate Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer.
M9818 Auristatin E Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity.
M9541 DM4 DM4, a chemical derivative of maytansine, is a potent and selective cytotoxic agent that inhibit cell division.
M9216 VcMMAE VcMMAE is an anti-mitotic compound, monomethylauristatin E (MMAE), linked by a lysosomal cleavable dipeptide, valine-citrulline (VC). *The compound is unstable in solutions, freshly prepared is recommended
M9010 Crolibulin Crolibulin (also known as EPC2407 and crinobulin) is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity.
M8967 Maytansinol Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent.
M6535 BTB-1 BTB-1 is a selective and ATP-competitive Kif18A inhibitor, with IC50 value of 1.69 μM.
M6292 Ansamitocin P 3 Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic.
M6278 Epothilone D Epothilone D is a potent microtubule stabilizer.

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