| Cat.No. | Name | Information |
|---|---|---|
| M3912 | Vinblastine sulfate | Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase. |
| M1970 | Paclitaxel | Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. |
| M1940 | Docetaxel | Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. |
| M55442 | Paclitaxel-d5 | Paclitaxel-d5 |
| M50218 | VLS-1488 | VLS-1488 is an orally active KIF18A inhibitor that inhibits KIF18A microtubule-dependent ATPase activity with an IC50 value of 0.016 μM. |
| M43814 | WAY-118959-A | WAY-118959-A is a potential microtubule acetylation inhibitor. |
| M30435 | Bis-ANS dipotassium | Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations. |
| M29256 | Davunetide | Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity. |
| M27799 | Dolastatin 10 | Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization. |
| M22468 | Sovilnesib (AMG 650) | Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 μM. |
| M22255 | Eribulin | Eribulin |
| M20601 | TAI-1 | TAI-1 is a first-in-class, potent, specific, orally active Hec1 inhibitor that disrupts the Hec1-Nek2 protein interaction. |
| M13692 | MMAF hydrochloride | MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. |
| M13690 | MMAE-d8 | D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor. |
| M13689 | Cevipabulin fumarate | Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line. |
| M10885 | sabizabulin | VERU-111 (ABI-231) is a highly potent, orally available α/β tubulin inhibitor with strong antiproliferative activity and an average IC for action on melanoma and prostate cancer cell lines50 The value is 5.2 nM. |
| M10750 | BNC105 | BNC105 IS A TUBULIN POLYMERIZATION INHIBITOR THAT IS RESISTANT TO PROLIFERATION AND DESTRUCTION OF TUMOR VASCULAR FUNCTION. |
| M10749 | Verubulin | Verubulin (MPC-6827) is a highly effective, broad-spectrum microtubule blocker with in vivo and in vitro cytotoxic activity, promising as a potential drug candidate for a wide range of cancers. |
| M10491 | Batabulin sodium | Batabulin (T138067) sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity, covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis. |
| M10393 | Eribulin mesylate | Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer. |
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