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Microtubule Microtubule


Cat.No.  Name Information
M1970 Paclitaxel Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells.
M3912 Vinblastine sulfate Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase.
M1940 Docetaxel Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity.
M20888 Epothilone A Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.
M20720 Vindesine sulfate Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS), a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
M20683 Parbendazole Parbendazole is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules.
M20647 SSE15206 SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.
M20601 TAI-1 TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
M20550 KHS101 hydrochloride KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks.
M19969 Tubulysin Tubulysin family are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, and are potent microtubule destabilizing agents.
M13694 Taltobulin hydrochloride Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
M13693 Taltobulin Taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
M13692 MMAF hydrochloride MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent.
M13691 Entasobulin Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity.
M13690 MMAE-d8 D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
M13689 Cevipabulin fumarate Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line.
M13688 Soblidotin Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization.
M11477 Colcemid Colcemid (Demecolcine) is an effective mitotic inhibitor. Colcemid binds tubulin and blocks cells for metaphase karyotype analysis. Colcemid can induce apoptosis and can be used in tumor research.
M10885 sabizabulin VERU-111 (ABI-231) is a highly potent, orally available α/β tubulin inhibitor with strong antiproliferative activity and an average IC for action on melanoma and prostate cancer cell lines50 The value is 5.2 nM.
M10749 Verubulin Verubulin (MPC-6827) is a highly effective, broad-spectrum microtubule blocker with in vivo and in vitro cytotoxic activity, promising as a potential drug candidate for a wide range of cancers.
M10491 Batabulin sodium Batabulin (T138067) sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity, covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis.
M10393 Eribulin mesylate Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer.

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