Inhibitors
Cat.No. | Name | Information |
---|---|---|
M1970 | Paclitaxel | Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells. |
M3912 | Vinblastine sulfate | Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase. |
M1940 | Docetaxel | Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. |
M11477 | Colcemid | Colcemid (Demecolcine) is an effective mitotic inhibitor. Colcemid binds tubulin and blocks cells for metaphase karyotype analysis. Colcemid can induce apoptosis and can be used in tumor research. |
M10885 | sabizabulin | VERU-111 (ABI-231) is a highly potent, orally available α/β tubulin inhibitor with strong antiproliferative activity and an average IC for action on melanoma and prostate cancer cell lines50 The value is 5.2 nM. |
M10750 | BNC105 | BNC105 IS A TUBULIN POLYMERIZATION INHIBITOR THAT IS RESISTANT TO PROLIFERATION AND DESTRUCTION OF TUMOR VASCULAR FUNCTION. |
M10749 | Verubulin | Verubulin (MPC-6827) is a highly effective, broad-spectrum microtubule blocker with in vivo and in vitro cytotoxic activity, promising as a potential drug candidate for a wide range of cancers. |
M10491 | Batabulin sodium | Batabulin (T138067) sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity, covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis. |
M10393 | Eribulin mesylate | Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer. |
M9818 | Auristatin E | Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. |
M9541 | DM4 | DM4, a chemical derivative of maytansine, is a potent and selective cytotoxic agent that inhibit cell division. |
M9216 | VcMMAE | VcMMAE is an anti-mitotic compound, monomethylauristatin E (MMAE), linked by a lysosomal cleavable dipeptide, valine-citrulline (VC). |
M9010 | Crolibulin | Crolibulin (also known as EPC2407 and crinobulin) is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. |
M8967 | Maytansinol | Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent. |
M6535 | BTB-1 | BTB-1 is a selective and ATP-competitive Kif18A inhibitor, with IC50 value of 1.69 μM. |
M6292 | Ansamitocin P 3 | Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic. |
M6278 | Epothilone D | Epothilone D is a potent microtubule stabilizer. |
M5626 | Estramustine phosphate sodium | Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. |
M5588 | Docetaxel Trihydrate | Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. |
M5392 | Albendazole Oxide | Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations. |
M5282 | INH6 | INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. |
M5222 | Mertansine | Mertansine is a tubulin inhibitor,inhibits the assembly of microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
M5068 | ELR510444 | ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines. |
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