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Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity.
| Molecular Weight | 824.92 |
| Formula | C36H60N10O12 |
| CAS Number | 211439-12-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 125 mg/mL (ultrasonic) Water 100 mg/mL (ultrasonic) |
| Storage | Store at ≤ -20°C, dry, sealed |
[2] Iddo Magen, et al. Curr Med Chem. Davunetide: Peptide therapeutic in neurological disorders
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