About 33 results found for searched term "Microtubule" (0.073 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M51438 | Microtubule-Associated Protein (142-161) (human) | Others |
| Microtubule-Associated Protein (142-161) (human) is a polypeptide that can be found by peptide screening. | ||
| M54752 | Recombinant Human Tau Protein (E. coli, His Tag) | Recombinant Proteins |
| MAPT; microtubule-associated protein tau | ||
| Tau proteins are proteins that stabilize microtubules. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. | ||
| M54754 | Recombinant Human Tau-F Protein (E.coli) | Recombinant Proteins |
| Microtubule-associated protein tau; MAPTL | ||
| Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. | ||
| M1940 | Docetaxel | Microtubule |
| Taxotere; RP-56976 | ||
| Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. | ||
| M1970 | Paclitaxel | Microtubule |
| Taxol; NSC 125973 | ||
| Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. | ||
| M1992 | 2-Methoxyestradiol | HIF |
| 2ME2 | ||
| 2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa. | ||
| M2274 | Fosbretabulin disodium | Microtubule |
| Combretastatin A-4 phosphate, CA4P | ||
| Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. | ||
| M2726 | Griseofulvin | Antibiotic |
| Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function. | ||
| M3194 | Nocodazole | Src-bcr-Abl |
| Oncodazole；R17934 | ||
| Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. | ||
| M3460 | Colchicine | Microtubule |
| Colchicine is a natural product extracted from Colchicum spp. It is also a tubulin inhibitor and microtubule disruptor with an IC50 of 3 nM for inhibition of microtubule polymerization, and a competitive antagonist of α3 glycine receptors (GlyRs). Colchicine is also a competitive antagonist of α3 Glycine receptors (GlyRs) and has been used in gout research. | ||
| M3492 | CYT997 | Microtubule |
| Lexibulin | ||
| CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. | ||
| M3768 | Ixabepilone | Microtubule |
| Ixempra, BMS-247550, NSC 710428 | ||
| Ixabepilone (BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. | ||
| M3797 | Remodelin | Histone Acetyltransferase |
| Remodelin is a novel, potent Acetyl-transferase NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. | ||
| M3901 | Combretastatin A4 | Microtubule |
| CRC 87-09, NSC 817373, CA-4 | ||
| Combretastatin A4 (CA-4), which is a natural stilbene isolated from Combretum caffrum, is a microtubule-destabilizing agent that binds to the colchicine domain on β-tubulin and exhibits a lower toxicity profile than paclitaxel or the Vinca alkaloids. | ||
| M4417 | 7-Epitaxol | Microtubule |
| 7-epi-Paclitaxel | ||
| 7-Epi-Taxol is the active metabolite of Taxol, which has similar effects to Taxol in inhibiting cell proliferation, microtubule dissociation and inducing microtubule polymerization. | ||
| M4780 | 4-Demethylepipodophyllotoxin | Microtubule |
| 4'-O-demethylepipodophyllotoxin; 4'-DMEP | ||
| 4 '- Demethylepipodophyllotoxin (4' - DMEP) is an intermediate compounds, can inhibit microtubule assembly. | ||
| M4857 | Epothilone B | Microtubule |
| Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. | ||
| M5068 | ELR510444 | Microtubule |
| ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines. | ||
| M5222 | Mertansine | Microtubule |
| DM1, Maytansinoid | ||
| Mertansine is a tubulin inhibitor，inhibits the assembly of microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). *The compound is unstable in solutions, freshly prepared is recommended | ||
| M5588 | Docetaxel Trihydrate | Microtubule |
| Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. | ||
| M5626 | Estramustine phosphate sodium | Microtubule |
| Estramustine phosphate disodium | ||
| Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. | ||
| M5975 | Sulfabenzamide | Autophagy |
| Sultrin, N-Sulfanilylbenzamide | ||
| Sulfabenzamide is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis. | ||
| M6278 | Epothilone D | Microtubule |
| 12,13-Desoxyepothilone B; Desoxyepothilone B; KOS 862 | ||
| Epothilone D is a potent microtubule stabilizer. | ||
| M6292 | Ansamitocin P 3 | Microtubule |
| Antibiotic C 15003P3; Maytansinol butyrate | ||
| Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic. | ||
| M6827 | Indibulin | Others |
| Indibulin is a microtubule destabilizer. | ||
| M7834 | HMBA | Others |
| HMBA is an Inhibitor of microtubule polymerization; apoptosis inducer. | ||
| M7843 | 5HPP-33 | Others |
| 5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. | ||
| M7923 | Myoseverin B | Others |
| Myoseverin, a new microtubule-binding molecule, acts reversibly on myoblast proliferation without the cytotoxic effects displayed by nonpurine-based microtubule-disrupting molecules, like taxol, vinblastine, nocodazole. | ||
| M8727 | IMB5046 | Others |
| IMB5046 is a microtubule inhibitor that has antitumor activity, overcoming multidrug-resistance. | ||
| M8826 | TN-16 | Others |
| Inhibitor of microtubule assembly. | ||
| M8835 | UA62784 | Others |
| Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor. | ||
| M8967 | Maytansinol | Microtubule |
| Ansamitocin P-0 | ||
| Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent. | ||
| M10052 | Fatostatin | FAS |
| Fatostatin A | ||
| Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division. | ||
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