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Estramustine phosphate sodium

Cat. No. M5626
Estramustine phosphate sodium Structure

Estramustine phosphate disodium

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50mg USD 110  USD110 In stock
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Biological Activity

Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.

Chemical Information
Molecular Weight 564.35
Formula C23H30Cl2NNa2O6P
CAS Number 52205-73-9
Solubility (25°C) 7.8 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Aurilio G, et al. Int J Clin Oncol. Estramustine phosphate sodium in heavily pretreated patients with metastatic breast cancer: a retrospective consecutive case series.

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Keywords: Estramustine phosphate sodium, Estramustine phosphate disodium supplier, Microtubule, inhibitors, activators

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