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Triclabendazole

Cat. No. M3086
Triclabendazole Structure
Synonym:

CGA89317

Size Price Availability Quantity
50mg USD 55  USD55 In stock
100mg USD 80  USD80 In stock
500mg USD 210  USD210 In stock
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Quality Control & Documentation
Biological Activity

Triclabendazole is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.

Chemical Information
Molecular Weight 359.66
Formula C14H9Cl3N2OS
CAS Number 68786-66-3
Form Solid
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Triclabendazole

[2] Luis Marcos, et al. Triclabendazole for the treatment of human fascioliasis and the threat of treatment failures

[3] Preetam Gandhi, et al. Triclabendazole in the treatment of human fascioliasis: a review

[4] No authors listed. Triclabendazole

[5] G P Brennan, et al. Understanding triclabendazole resistance

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Keywords: Triclabendazole, CGA89317 supplier, Microtubule, inhibitors, activators


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