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Vinblastine sulfate ia a plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Vinblastine sulfate inhibits normal microtubule assembly and causes aberrant tubulin polymerization. Vinblastine sulfate blocks binding of tubulin to microtubule proteins.Vinblastine sulfate Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent. Vinblastine sulfate is a microtubule disrupter. Vinblastine sulfate induces apoptosis in cultured hepatocytes and human lymphoma cells.Vinblastine sulfate shown to inhibit autophagosome maturation.
Exp Mol Med. 2018 Oct 16;50(10):136.
Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors.
Vinblastine sulfate purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Chinese hamster ovary (CHO) cells |
| Preparation method | Six-well treatment plates are set up that contained 5 ×104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with vinblastine for 3 h followed by 21 h growth. |
| Concentrations | 1% (v/v) (dissolved in DMSO) |
| Incubation time | 3h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 909.05 |
| Formula | C46H60N4O13S |
| CAS Number | 143-67-9 |
| Solubility (25°C) | Water 40 mg/mL DMSO 44 mg/mL |
| Storage | -20°C, protect from light, sealed |
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