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Vinblastine sulfate

Cat. No. M3912
Vinblastine sulfate Structure
Synonym:

Vincaleukoblastine sulfate salt

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 36  USD36 In stock
10mg USD 58  USD58 In stock
50mg USD 100  USD100 In stock
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Biological Activity

Vinblastine sulfate ia a plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Vinblastine sulfate inhibits normal microtubule assembly and causes aberrant tubulin polymerization. Vinblastine sulfate blocks binding of tubulin to microtubule proteins.Vinblastine sulfate Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent. Vinblastine sulfate is a microtubule disrupter. Vinblastine sulfate induces apoptosis in cultured hepatocytes and human lymphoma cells.Vinblastine sulfate shown to inhibit autophagosome maturation.

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines Chinese hamster ovary (CHO) cells
Preparation method Six-well treatment plates are set up that contained 5 ×104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with vinblastine for 3 h followed by 21 h growth.
Concentrations 1% (v/v) (dissolved in DMSO)
Incubation time 3h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 909.05
Formula C46H60N4O13S
CAS Number 143-67-9
Solubility (25°C) Water 40 mg/mL
DMSO 44 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fan M, et al. J Biol Chem. Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade.

[2] Tashiro E, et al. Jpn J Cancer Res. Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small cell lung carcinoma Ms-1 cells.

[3] Jordan MA, et al. Cancer Res. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro.

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Keywords: Vinblastine sulfate, Vincaleukoblastine sulfate salt supplier, Microtubule, inhibitors, activators


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