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Eribulin mesylate inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin (1-10 nM) induces morphological change and suppresses cell migration in a low concentration in LM8 cells.
In vivo, Eribulin (1 mg/kg; i.v. once a week for 2 weeks) reduces primary tumor growth and lung metastasis of osteosarcoma in mice.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 826.00 |
| Formula | C41H63NO14S |
| CAS Number | 441045-17-6 |
| Purity | >99% |
| Solubility | DMSO 90 mg/mL |
| Storage | -20°C, protect from light, sealed |
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