All AbMole products are for research use only, cannot be used for human consumption.
Crolibulin is a small molecule tubulin polymerization inhibitor. Microtubulin inhibitor Crolibulin (EPC2407) binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. Crolibulin also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.
| Molecular Weight | 417.26 |
| Formula | C18H17BrN4O3 |
| CAS Number | 1000852-17-4 |
| Solubility (25°C) | DMSO: ≥ 90 mg/mL (Need warming and ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Patil SA, et al. Future Med Chem. Chromenes: potential new chemotherapeutic agents for cancer.
| Related Microtubule Products |
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CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity. |
| Lisavanbulin
Lisavanbulin (BAL-101553) is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862). |
| 20-O-Demethyl-AP3
20-O-Demethyl-AP3 is a minor metabolite of Ansamitocin P-3. |
| Lisavanbulin dihydrochloride
Lisavanbulin (BAL-101553) dihydrochloride is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862). |
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Paclitaxel-d5 |
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