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VcMMAE

Cat. No. M9216
VcMMAE Structure
Synonym:

MC-VC-PAB-MMAE; MMAE Vc linker

Size Price Availability Quantity
5mg USD 105  USD105 In stock
10mg USD 185  USD185 In stock
50mg USD 560  USD560 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30+ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells. MMAE sensitized colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. In vivo, Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolonged tumor regression in xenograft models.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1316.63
Formula C68H105N11O15
CAS Number 646502-53-6
Purity >99%
Solubility DMSO: ≥ 42 mg/mL
Storage 4°C, protect from light, dry, sealed
References

[1] Buckel L, et al. Cancer Res. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.

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  Catalog
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Keywords: VcMMAE, MC-VC-PAB-MMAE; MMAE Vc linker supplier, Microtubule, inhibitors

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