Free shipping on all orders over $ 500


Cat. No. M9216
VcMMAE Structure


Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 87  USD87 In stock
25mg USD 200  USD200 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30+ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells. MMAE sensitized colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. In vivo, Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolonged tumor regression in xenograft models.

*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information
Molecular Weight 1316.63
Formula C68H105N11O15
CAS Number 646502-53-6
Solubility (25°C) DMSO: ≥ 42 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Buckel L, et al. Cancer Res. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.

Related Microtubule Products
Taccalonolide AJ

Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity.


Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization.


Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris.


WAY-118959-A is a potential microtubule acetylation inhibitor.

ER degrader 7

ER degrader 7 is an ERα and ERβ degrader.

Abmole Inhibitor Catalog

Keywords: VcMMAE, MC-VC-PAB-MMAE; MMAE Vc linker; MC-Val-Cit-PAB-MMAE supplier, Microtubule, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.