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VcMMAE

Cat. No. M9216
VcMMAE Structure
Synonym:

MC-VC-PAB-MMAE; MMAE Vc linker; MC-Val-Cit-PAB-MMAE

Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 87  USD87 In stock
25mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30+ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells. MMAE sensitized colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. In vivo, Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolonged tumor regression in xenograft models.

*The compound is unstable in solutions, freshly prepared is recommended



Chemical Information
Molecular Weight 1316.63
Formula C68H105N11O15
CAS Number 646502-53-6
Solubility (25°C) DMSO: ≥ 42 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Buckel L, et al. Cancer Res. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.

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Keywords: VcMMAE, MC-VC-PAB-MMAE; MMAE Vc linker; MC-Val-Cit-PAB-MMAE supplier, Microtubule, inhibitors, activators


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