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BTB-1 is a selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.69 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.
| Molecular Weight | 297.71 |
| Formula | C12H8ClNO4S |
| CAS Number | 86030-08-2 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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