About 32 results found for searched term "T-2 Toxin" (0.113 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14982 | Zearalenone | Estrogen Receptor |
| Mycotoxin F2; Toxin F2 | ||
| Zearalenone is a mycotoxin obtained from Fusarium oxysporum and a non-steroidal oestrogen that acts by binding to the oestrogen receptor (ER) and has endocrine modulating or disrupting functions in animals. | ||
| M40106 | HT-2 Toxin | Others |
| HT-2 Toxin is an active, deacetylated metabolite of the T-2 toxin. HT-2 toxin inhibits protein synthesis and cell proliferation in plants. | ||
| M55394 | T-2 Toxin | Apoptosis |
| T-2 Mycotoxin | ||
| T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains. T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides. | ||
| M2326 | Etoposide (VP-16-213) | Topoisomerase |
| VP-16-213; Vepesid; NSC 141540 | ||
| Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. | ||
| M2327 | Daunorubicin hydrochloride | DNA/RNA Synthesis |
| Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride | ||
| Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. | ||
| M4012 | Licochalcone-A | Autophagy |
| Licochalcone-A; Lico A | ||
| Licochalcone A is an estrogenic flavonoid derived from licorice that induces Nrf2-mediated defense mechanisms and ameliorates acetaminophen and endotoxin-induced liver injury. In addition, Licochalcone A has antimalarial, anticancer, antibacterial and antiviral activities. | ||
| M8438 | Retro-2 cycl | Anti-infection |
| RN 1-001 | ||
| Retro-2 cycl is a non-toxic inhibitor of the endosome-to-Golgi retrograde transport that selectively protect cells from ricin, cholera toxin, and Shiga-like toxins, without affecting compartment morphology, endogenous retrograde cargos, or other trafficking steps. | ||
| M8601 | R-Ketorolac | Others |
| R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. | ||
| M10407 | PNU-159682 | Topoisomerase |
| PNU159682; metabolite of nemorubicin (MMDX) | ||
| PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes, it is a highly potent DNA topoisomerase I inhibitor with excellent cytotoxicity. PNU-159682 is a potent ADCs cytotoxin. | ||
| M11378 | Cardiotoxin Analog (CTX) IV (6-12) | Others |
| Cardiotoxin Analog (CTX) IV (6-12) is a Cardiotoxin analogue IV. Cardiotoxin Analogues IV, isolated from the venom of the Taiwan cobra, is a unique snake venom Cardiotoxin. | ||
| M14968 | Cardiotoxin Analog (CTX) IV (6-12) (TFA) | Others |
| Cardiotoxin Analog (CTX) IV (6-12) (TFA) is a part peptide of Cardiotoxin Analog (CTX) IV. Cardiotoxin analogues IV isolated from the venom of Taiwan Cobra. CTX IV is an unique snake venom cardiotoxin. | ||
| M24536 | Moxetumomab pasudotox | Drug-Linker Conjugates for ADC |
| CAT 8015; HA 22 Anti-Human CD22 Recombinant Antibody | ||
| Moxetumomab pasudotox (CAT 8015) is anti-CD22 immunotoxin containing an anti-CD22 Fv and Pseudomonas exotoxin. CD22 is a cell surface receptor expressed on a variety of malignant B-cells. Moxetumomab pasudotox can be used in the research of hairy cell leukemia (HCL). | ||
| M24741 | Moxetumomab | Others |
| Moxetumomab, a recombinant CD22-targeting immunotoxin, can be used for the research of hairy cell leukemia (HCL). | ||
| M24744 | Laprituximab emtansine | EGFR/HER2 |
| IMGN-289; J2898A-SMCC-DM1 | ||
| Laprituximab emtansine (IMGN-289) is an immunotoxin targeting HER1. Laprituximab emtansine is an EGFR antibody-drug conjugate (ADC) consisting of the J2898A antibody, DM1 (anti-microtubule agent) and the SMCC thioether linker. Laprituximab emtansine can be used for cancer research. | ||
| M24791 | Denileukin diftitox | IL Receptor/Related |
| DAB 389IL-2; E7777; LY335348 | ||
| Denileukin diftitox (DAB 389IL-2) is a diphtheria toxin (DT)-related interleukin 2 (IL-2) fusion protein toxin that depletes cells expressing the high-affinity form of the IL-2 receptor (IL-2R), CD25. Denileukin diftitox binds to cells expressing IL-2R and inhibits protein synthesis through internalization of the diphtheria toxin fragment. | ||
| M25279 | Baminercept | Others |
| BG 9924; TT-47 | ||
| Baminercept (BG 9924) is a lymphotoxin β receptor IgG fusion protein (LTβR-Ig). Baminercept can be used for the research of many autoimmune diseases including primary Sjögren's syndrome (SS) and rheumatoid arthritis (RA) . | ||
| M25290 | Topsalysin | Others |
| PRX-302; PRX302 PSA-PAH1 | ||
| Topsalysin (PRX-302; PRX302; PSA-PAH1) is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle. | ||
| M25465 | B022 | NF-κB |
| B-022 | ||
| B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 4.2 nM and IC50 of 15.1 nM. B022 protects liver from toxin-induced inflammation, oxidative stress and injury. | ||
| M28492 | Margatoxin | Potassium Channel |
| Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research. | ||
| M29943 | T-2 Triol | Metabolite/Endogenous Metabolite |
| T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin. T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t1/2λz), Peak plasma concentrations (Cmax) and Tmax values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively. | ||
| M29970 | BoNT-IN-2 | Others |
| BoNT-IN-2 (Compound 33) is a Botulinum Neurotoxin A Light Chain (BoNT/A LC) inhibitor with an IC50 of 4.5 μM. | ||
| M30536 | Aflatoxin B2 | Antibiotic |
| Aflatoxin B2 is a major naturally produced aflatoxin. Aflatoxin B2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2. | ||
| M31232 | ω-Agatoxin IVA TFA | Calcium Channel |
| ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA TFA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA also blocks the high potassium-induced release of serotonin and norepinephrine. | ||
| M31233 | ω-Agatoxin IVA | Calcium Channel |
| ω-Agatoxin IVA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. | ||
| M38651 | Hexa-D-arginine TFA | Antibiotic |
| Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo. | ||
| M38678 | Aflatoxin G2 | Antibiotic |
| Aflatoxin G2 is a major naturally produced aflatoxin. Aflatoxin G2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2. | ||
| M38679 | Aflatoxin M1 | Antibiotic |
| Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2. | ||
| M38792 | Aflatoxin M2 | Parasite |
| Aflatoxin M2 is a major metabolite of Aflatoxin B1. Aflatoxin M2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2. | ||
| M38917 | 2-Aminofluorene | DNA/RNA Synthesis |
| 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis. | ||
| M49427 | α-Conotoxin MII TFA | AChR/AChE |
| α-CTxMII TFA | ||
| α-Conotoxin MII TFA, a natural product isolated from the sea snail Conus magus, can effectively inhibit the α3β2 subunit of the nAChR receptor, with an IC50 value of 0.5 nM. In addition, α-Conotoxin MII TFA can effectively inhibit the activity of β3-containing neuro-nicotinic receptor. | ||
| M50931 | SNAP-25 (187-203) | Others |
| SNAP-25 (187-203), a peptide corresponding to residues 187–203 of SNAP-25, is a substrate for botulinum neurotoxin (BoNT)/A and can be used as a substrate for quantifying the activity of BoNT/C1(1-430) . | ||
| M52740 | Heteropodatoxin-2 | Potassium Channel |
| Heteropodatoxin-2, a peptides of 30-amino acid, is a heteropodatoxin. | ||
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