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R-Ketorolac

Cat. No. M8601

All AbMole products are for research use only, cannot be used for human consumption.

R-Ketorolac Structure

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Quality Control & Documentation
Biological Activity

R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. R-ketorolac significantly inhibits ovarian cancer cell adhesion, migration, and invasion.

Chemical Information
Molecular Weight 255.27
Formula C15H13NO3
CAS Number 66635-93-6
Solubility (25°C) DMSO: 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Martha M Grimes, et al. The R-enantiomer of ketorolac reduces ovarian cancer tumor burden in vivo

[2] Laurie G Hudson, et al. Dual Actions of Ketorolac in Metastatic Ovarian Cancer

[3] Amanda S Peretti, et al. The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice

[4] Aida Kulo, et al. Enantiomer-specific ketorolac pharmacokinetics in young women, including pregnancy and postpartum period

[5] Yuna Guo, et al. R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis

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Keywords: R-Ketorolac supplier, inhibitors, activators

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