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Laprituximab emtansine

Cat. No. M24744

All AbMole products are for research use only, cannot be used for human consumption.

Laprituximab emtansine Structure
Synonym:

IMGN-289; J2898A-SMCC-DM1

Price and Availability

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Quality Control & Documentation
Biological Activity

Laprituximab emtansine (IMGN-289) is an immunotoxin targeting HER1. Laprituximab emtansine is an EGFR antibody-drug conjugate (ADC) consisting of the J2898A antibody, DM1 (anti-microtubule agent) and the SMCC thioether linker. Laprituximab emtansine can be used for cancer research.

Chemical Information
CAS Number 1622327-37-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Gunter von Minckwitz, et al. N Engl J Med. Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer

[2] Sara A Hurvitz, et al. Lancet Oncol. Neoadjuvant trastuzumab, pertuzumab, and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer (KRISTINE): a randomised, open-label, multicentre, phase 3 trial

[3] Sibylle Loibl, et al. Lancet. HER2-positive breast cancer

[4] Mark Barok, et al. Breast Cancer Res. Trastuzumab emtansine: mechanisms of action and drυg resistance

[5] Sunil Verma, et al. N Engl J Med. Trastuzumab emtansine for HER2-positive advanced breast cancer

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Keywords: Laprituximab emtansine, IMGN-289; J2898A-SMCC-DM1 supplier, EGFR/HER2, inhibitors, activators

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