About 30 results found for searched term "Sodium Channel" (0.062 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1876 | Valproic acid sodium | HDAC |
| Sodium valproate | ||
| Valproic acid (VPA) sodium is a histone deacetylase inhibitor which is reported to enhance central GABAergic neurotransmission and inhibit Na+ channels. Valproic acid (VPA) sodium is also an SSADH inhibitor. | ||
| M1968 | Riluzole | Sodium Channel |
| Rilutek, PK-26124, RP-54274 | ||
| Rilutek is a sodium channel protein inhibitor and a new mental compound, which has anticonvulsant, hypnotic, antianxiety, antiischemia and anesthesia properties. Riluzole belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM. | ||
| M2210 | A-803467 | Sodium Channel |
| A803467 | ||
| A-803467 is a potent and selective Nav1.8 sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM). | ||
| M2487 | Camostat mesylate | Sodium Channel |
| FOY-305; Camostat Mesilate; FOY-S980 | ||
| Camostat mesylate is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase. | ||
| M2632 | Dibucaine hydrochloride | Animal experimental anesthetics |
| Cinchocaine HCl | ||
| Dibucaine (Cinchocaine) hydrochloride is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor. Dibucaine hydrochloride is a local anesthetics. | ||
| M2802 | Lamotrigine | Sodium Channel |
| LTG; BW430C | ||
| Lamotrigine is a novel anticonvulsant compound for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker. | ||
| M2810 | Levobupivacaine hydrochloride | Animal experimental anesthetics |
| (S)-(-)-Bupivacaine monohydrochloride | ||
| Levobupivacaine hydrochloride is a long-acting amide local anaesthetic. Levobupivacaine hydrochloride exerts anaesthetic and analgesic effects through reversible blockade of neuronal sodium channel. | ||
| M2847 | Mexiletine hydrochloride | Sodium Channel |
| Mexiletine hydrochloride inhibits sodium channels to reduce the inward sodium current. | ||
| M2877 | Nefopam hydrochloride | Wnt/beta-catenin |
| Fenazoxine hydrochloride | ||
| Nefopam hydrochloride is an centrally-acting but non-opioid analgesic compound by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake. | ||
| M2961 | Procaine hydrochloride | Sodium Channel |
| Novocaine HCl | ||
| Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M3345 | Primidone | Calcium Channel |
| NCI-C56360 | ||
| Primidone is an anticonvulsant of the pyrimidinedione class. Primidone is a neuronal voltage-gated sodium channel (VGSC) blocker and can be used for the study of epilepsy, essential tremor, and Psychiatric disorders. | ||
| M3354 | Carbamazepine | Sodium Channel |
| CBZ; NSC 169864 | ||
| Carbamazepine is a sodium channel inhibitor with an IC50 of 131 μM when treated with synaptosomes in rat brain. It can be used in trigeminal neuralgia research. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50=2 μM). | ||
| M3358 | Procainamide hydrochloride | Sodium Channel |
| Procaine amide hydrochloride; SP 100 hydrochloride | ||
| Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor. | ||
| M3366 | Amiloride hydrochloride dihydrate | Sodium Channel |
| MK-870 hydrochloride dihydrate | ||
| Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker. | ||
| M3386 | Amiloride hydrochloride | Sodium Channel |
| MK-870 hydrochloride | ||
| Amiloride hydrochloride, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. | ||
| M3412 | Propafenone hydrochloride | Sodium Channel |
| Propafenone HCl is a sodium-channel blocker that also has a high affinity for β-receptors (IC50 = 32 nM). It blocks transient outward potassium current (Ito) and sustained delayed rectifier K+ current (Isus) with IC50 values of 4.9 μM and 8.6 μM, respectively.In addition, Propafenone inhibits the proliferation of esophageal cancer by inducing mitochondrial dysfunction and apoptosis. | ||
| M3418 | Bupivacaine hydrochloride | Animal experimental anesthetics |
| Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain. | ||
| M3456 | Chlorpromazine hydrochloride | Potassium Channel |
| Sonazine | ||
| Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M5570 | Dibucaine | Animal experimental anesthetics |
| Cinchocaine | ||
| Dibucaine (Cinchocaine) is a sodium channel inhibitor. Dibucaine is a potent SChE inhibitor. Dibucaine is a local anesthetic of the amide type now generally used for surface anesthesia. | ||
| M5603 | Dyclonine HCl | Animal experimental anesthetics |
| Dyclocaine hydrochloride | ||
| Dyclonine HCl is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation. | ||
| M5741 | Lidocaine | Animal experimental anesthetics |
| Alphacaine | ||
| Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Lidocaine (Lignocaine) also inhibits sodium channels involving complex voltage and using dependence. | ||
| M5871 | Permethrin | Parasite |
| NRDC-143 | ||
| Permethrin is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation. | ||
| M5876 | Phenytoin Sodium | Sodium Channel |
| Diphenylhydantoin Sodium | ||
| Phenytoin Sodium is a potent Voltage-gated Na+ channels (VGSCs) blocker. | ||
| M5897 | Prilocaine | Sodium Channel |
| NSC 40027 | ||
| Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. | ||
| M5899 | Procaine | Animal experimental anesthetics |
| Novocaine, Vitamin H3, Duracaine, Spinocaine | ||
| Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M5904 | Proparacaine HCl | Sodium Channel |
| Proxymetacaine Hydrochloride | ||
| Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM. | ||
| M5943 | Rufinamide | Sodium Channel |
| CGP 33101 | ||
| Rufinamide is a voltage-gated sodium channel blocker, used an anticonvulsant medication. | ||
| M6054 | Vinpocetine | Sodium Channel |
| RGH-4405 | ||
| Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease. | ||
| M6068 | Zonisamide | Sodium Channel |
| CI-912 | ||
| Zonisamide is an fDA-approved antiepileptic compound that blocks voltage-dependent sodium (+) and T-type calcium channels. | ||
| M6085 | Raxatrigine | Sodium Channel |
| GSK-1014802; CNV-1014802; Vixotrigine | ||
| Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. | ||
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