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Dyclonine HCl

Cat. No. M5603
Dyclonine HCl Structure
Synonym:

Dyclocaine hydrochloride

Size Price Availability Quantity
1g USD 40  USD40 In stock
5g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Dyclonine HCl is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation. Dyclonine (Dyclocaine) hydrochloride is also an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 µM for ALDH2 and 76 µM for ALDH3A1.

Chemical Information
Molecular Weight 325.87
Formula C18H27NO2.HCl
CAS Number 536-43-6
Solubility (25°C) Water 40 mg/mL
DMSO 20 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sahdeo S, et al. Hum Mol Genet. Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia.

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