About 30 results found for searched term "INH6" (0.046 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2114 | GSK126 | EZH2 |
| EZH2 inhibitor; GSK2816126A | ||
| GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. | ||
| M2659 | E-64 | Autophagy |
| Proteinase inhibitor E 64 | ||
| E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. | ||
| M2785 | JNK Inhibitor IX (SC202671) | JNK |
| TCS JNK 5a; SC-202671 | ||
| JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. | ||
| M5282 | INH6 | Microtubule |
| INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. | ||
| M8206 | PDI inhibitor 16F16 | Others |
| 16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. | ||
| M9642 | EGFR inhibitor 324674 | EGFR/HER2 |
| EGFR-IN-12 | ||
| EGFR inhibitor 324674 is a cell permeable, potent and selective EGFR inhibitor with IC50 of 21 nM. | ||
| M14255 | IK1 inhibitor PA-6 | Potassium Channel |
| PA-6 | ||
| IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. | ||
| M14905 | PKA Inhibitor Fragment (6-22) amide TFA | PKA |
| PKI-(6-22)-amide TFA | ||
| PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse low-level morphine antinociceptive tolerance in mice. | ||
| M20596 | K-Ras(G12C) inhibitor 6 | ROCK |
| K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C). | ||
| M20680 | IRAK inhibitor 6 | IRAK |
| IRAK inhibitor 6 is a selective Interleukin-1 receptor-associated kinase 4(IRAK4) inhibitor with IC50 of 0.16 μM. | ||
| M20707 | RK 24466 | Src-bcr-Abl |
| KIN 001-51, Lck inhibitor C 8863, C8863 | ||
| RK-24466 (KIN 001-51) is a potent and selective inhibitor of Lck that inhibits two constructs of the human lck kinase, lck (64-509) and lckcd with IC50 of < 0.001 μM and 0.002 μM, respectively. | ||
| M22513 | Mcl-1 inhibitor 6 | Bcl-2 |
| Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a Kd of 0.23 nM and a Ki of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, Kd>10 μM). | ||
| M27728 | Tubulin inhibitor 6 | Microtubule |
| Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM. | ||
| M29486 | SHP2 inhibitor LY6 | Phosphatase |
| LY6 | ||
| SHP2 inhibitor LY6 (LY6) is potent and selective inhibitor of SHP2, with an IC50 of 9.8 µM. SHP2 inhibitor LY6 can inhibits SHP2-mediated cell signaling and proliferation. | ||
| M29603 | FAK inhibitor 6 | FAK |
| Compound 26F not only optimized the effective inhibitory enzyme (ic50= 28.2 nm), but also showed relatively less cytotoxicity (ic50= 3.32 μ M) And induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in g0/g1 phase. | ||
| M30630 | p32 Inhibitor M36 | PKC |
| M36 | ||
| p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1. | ||
| M40641 | Recombinant Mouse MIF Protein (E.coli, C-6His) | Cytokines and Growth Factors |
| Macrophage migration inhibitory factor; DER6 | ||
| Macrophage migration inhibitory factor (MIF) is a secreted protein and belongs to the MIF family. MIF is an important regulator of innate immunity. The circulating MIF binds to CD74 on other immune cells to trigger an acute immune response. Hence MIF is classified as an inflammatory cytokine. Furthermore glucocorticoids also stimulate white blood cells to release MIF and hence MIF partially counter acts the inhibitory effects that glucocorticoids have on the immune system. Finally trauma activates the anterior pituitary gland to release MIF. | ||
| M41038 | Tuberculosis inhibitor 6 | Antibiotic |
| Tuberculosis inhibitor 6 is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis. | ||
| M41318 | Mcl-1 inhibitor 16 | Bcl-2 |
| Mcl-1 inhibitor 16 is a mitochondrial targeting Platinum-based inhibitor of Mcl-1. | ||
| M41410 | ATM Inhibitor-6 | ATM/ATR |
| ATM inhibitor-6 (A-193) is a selective ATM kinase inhibitor. | ||
| M41520 | Tubulin inhibitor 36 | Microtubule |
| Tubulin inhibitor 36 is a novel and potent tubulin inhibitor and inhibits the polymerization of microtubular protein then induces apoptosis with an IC50 value of 1.5±0.1 μM. | ||
| M41601 | SIRT5 inhibitor 6 | Sirtuin |
| SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM. | ||
| M41609 | Topoisomerase II inhibitor 16 | Topoisomerase |
| Topoisomerase II inhibitor 16 is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. | ||
| M42104 | Pim-1 kinase inhibitor 6 | Pim |
| Pim-1 kinase inhibitor 6 is a potent Pim-1 kinase inhibitor with IC50 value of 0.46 μM, and has significant cytotoxic effect on cancer cells. | ||
| M42117 | KRAS G12C inhibitor 61 | ERK |
| KRAS G12C inhibitor 61 inhibits phospho-ERK 1/2 in MIA PaCa-2 cells with an IC50 value of 9 nM. | ||
| M42125 | JNK3 inhibitor-6 | JNK |
| JNK3 inhibitor-6 is a selective JNK3 Inhibitor (IC50=78 nM). | ||
| M42269 | URAT1 inhibitor 6 | URAT1 |
| URAT1 inhibitor 6 is a potent URAT1 inhibitor (IC50: 35 nM for hURAT1). | ||
| M42392 | sEH inhibitor-16 | Epoxide Hydrolase |
| sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. | ||
| M45288 | Casein Kinase inhibitor A86 | Casein Kinase |
| Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor that also inhibits CDK7 (TFIIH) and CDK9 (P-TEFb). In addition, Casein Kinase inhibitor A86 induces apoptosis in leukemia cells and may be used in leukemia-related studies. | ||
| M49704 | ERK1/2 inhibitor 6 | ERK |
| ERK1/2 inhibitor 6 is a potent inhibitor of ERK1/2. | ||
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