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EGFR inhibitor 324674 (EGFR-IN-12) is a cell permeable, potent and selective EGFR inhibitor with IC50 of 21 nM. EGFR inhibitor 324674 (EGFR-IN-12) inhibits mutant EGFRL858R and EGFRL861Q with IC50s of 63 nM and 4 nM, respectively. EGFR inhibitor 324674 (EGFR-IN-12) also inhibits HT29 and SW480 cell proliferation with with IC50s of 1.96 µM and 1.04 µM, respectively.
| Molecular Weight | 413.40 |
| Formula | C21H18F3N5O |
| CAS Number | 879127-07-8 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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