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p32 Inhibitor M36

Cat. No. M30630
p32 Inhibitor M36 Structure
Synonym:

M36

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Biological Activity

p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1.

Chemical Information
Molecular Weight 448.52
Formula C23H28N8O2
CAS Number 802555-85-7
Form Solid
Solubility (25°C) DMSO 5 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Venkata Yenugonda, et al. J Transl Med. A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma

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Keywords: p32 Inhibitor M36, M36 supplier, PKC, inhibitors, activators


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