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p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1.
p32 Inhibitor M36 inhibits SF188 glioma cells proliferation (IC50 of 77.9 μM in complete media) and is much more potent under low glucose conditions with an IC50 of 7.3 μM. p32 Inhibitor M36 is selective for p32 overexpressing cells. p32 Inhibitor M36 is also a potent inhibitor of neurospheres with an IC50 of 2.8 μM.
| Molecular Weight | 448.52 |
| Formula | C23H28N8O2 |
| CAS Number | 802555-85-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mg/mL (ultrasonic and adjust pH to 2 with 1M HCl) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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