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Tubulin inhibitor 6 

Cat. No. M27728

All AbMole products are for research use only, cannot be used for human consumption.

Tubulin inhibitor 6  Structure

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Quality Control & Documentation
Biological Activity

Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM.

Chemical Information
Molecular Weight 367.85
Formula C20H14ClNO2S
CAS Number 105925-39-1
Form Solid
Solubility (25°C) DMSO 62.5 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hairong Tang, et al. Bioorg Chem. Discovery of a 2,6-diarylpyridine-based hydroxamic acid derivative as novel histone deacetylase 8 and tubulin dual inhibitor for the treatment of neuroblastoma

[2] Tobias Mühlethaler, et al. Angew Chem Int Ed Engl. Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action

[3] Alessandro Andreis, et al. Intern Emerg Med. Colchicine efficacy and safety for the treatment of cardiovascular diseases

[4] Shanthi Nagarajan, et al. Chem Biol Drug Des. Tubulin inhibitor identification by bioactive conformation alignment pharmacophore-guided virtual screening

[5] Masahiro Kizaki, et al. Curr Med Chem. New tubulin polymerization inhibitor derived from thalidomide: implications for anti-myeloma therapy

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Keywords: Tubulin inhibitor 6  supplier, Microtubule, inhibitors, activators

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