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Recombinant Mouse MIF Protein (E.coli, C-6His)

Cat. No. M40641

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse MIF Protein (E.coli, C-6His) Structure
Synonym:

Macrophage migration inhibitory factor; DER6

Size Price Availability Quantity
10ug USD 200  USD200 In stock
50ug USD 500  USD500 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Macrophage migration inhibitory factor (MIF) is a secreted protein and belongs to the MIF family. MIF is an important regulator of innate immunity. The circulating MIF binds to CD74 on other immune cells to trigger an acute immune response. Hence MIF is classified as an inflammatory cytokine. Furthermore glucocorticoids also stimulate white blood cells to release MIF and hence MIF partially counter acts the inhibitory effects that glucocorticoids have on the immune system. Finally trauma activates the anterior pituitary gland to release MIF.

Recombinant Mouse MIF Protein expressed the target gene encoding Pro2-Ala115, with a 6His tag at the C-terminus.


Accession: P34884

Apparent Molecular Weight: 10-14 KDa, reducing conditions

Endotoxin < 1 EU/µg

Lyophilized from a 0.2 μm filtered solution of PBS, 0.02% Tween 80, 4.0% Mannitol, 4.0% Sucrose, pH7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months.
References

[1] Jie Liu et al. Life Sci. Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease

[2] Lin Chen et al. Pharmacol Res. CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis

[3] Hyein Jeong et al. J Immunother Cancer. Recombinant Mycobacterium smegmatis delivering a fusion protein of human macrophage migration inhibitory factor (MIF) and IL-7 exerts an anticancer effect by inducing an immune response against MIF in a tumor-bearing mouse model

[4] Shanshan Song et al. EBioMedicine. D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling

[5] Christian Stoppe et al. Sci Transl Med. The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery

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Keywords: Recombinant Mouse MIF Protein (E.coli, C-6His), Macrophage migration inhibitory factor; DER6 supplier, Cytokines and Growth Factors, inhibitors, activators

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