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FAK inhibitor 6 

Cat. No. M29603

All AbMole products are for research use only, cannot be used for human consumption.

FAK inhibitor 6  Structure

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Quality Control & Documentation
Biological Activity

Compound 26F not only optimized the effective inhibitory enzyme (ic50= 28.2 nm), but also showed relatively less cytotoxicity (ic50= 3.32 μ M) And induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in g0/g1 phase.

Chemical Information
Molecular Weight 477.55
Formula C25H24FN5O2S
CAS Number 2410056-27-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Daniel S Reich, et al. Lancet Neurol. Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial

[2] Xinhua Song, et al. J Hepatol. Focal adhesion kinase (FAK) promotes cholangiocarcinoma development and progression via YAP activation

[3] Chang Li, et al. Oncol Res. Erratum

[4] Ozge Saatci, et al. Nat Commun. Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer

[5] Rongkun Li, et al. Mol Cancer. Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis

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  Catalog
Abmole Inhibitor Catalog




Keywords: FAK inhibitor 6  supplier, FAK, inhibitors, activators

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