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FAK Focal adhesion kinase

Inhibitors

Cat.No.  Name Information
M2302 PF-562271 PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.
M2931 PF-573228 PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.
M10508 BI-4464 BI-4464 is a novel highly selective ATP competitive inhibitor of PTK2/FAK with IC50 of 17 nM, it is also a PTK2 ligand for PROTAC.
M9256 Solanesol Solanesol (Nonaisoprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK.
M8945 Defactinib hydrochloride Defactinib hydrochloride is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
M6139 GSK2256098 GSK2256098 is a potent, selective, reversible, and ATP competitive FAK kinase inhibitor with apparent Ki of 0.4 nM.
M5347 Y15 Y15 is a novel small molecule FAK phosphorylation inhibitor; specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK.
M5334 PF-431396 PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.
M4978 PND-1186 PND-1186 (VS-4718) is a reversible and selective FAK inhibitor with IC50 of 1.5 nM.
M4872 Defactinib Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor.
M3286 PF-00562271 PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
M2931 PF-573228 PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.
M2302 PF-562271 PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.
M2301 NVP-TAE226 Nvp-tae 226 (TAE226) is a potent atP-competitive dual FAK and IGF-1R inhibitor with IC50 of 5.5 nM and 140 nM, respectively. Nvp-tae 226 (TAE226) also effectively inhibited Pyk2, insulin receptor (InsR), with IC50 of 3.5 nM and 40 nM.



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