Free shipping on all orders over $ 500

BI-4464

Cat. No. M10508
BI-4464 Structure
Synonym:

BI4464

Size Price Availability Quantity
5mg USD 450  USD450 In stock
10mg USD 740  USD740 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BI-4464 is a novel highly selective ATP competitive inhibitor of PTK2/FAK with IC50 of 17 nM, it is also a PTK2 ligand for PROTAC.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 555.55
Formula C28H28F3N5O4
CAS Number 1227948-02-8
Purity >98%
Solubility DMSO 16 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Johannes Popow, et al. J Med Chem. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

Related FAK Products
Solanesol

Solanesol (Nonaisoprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK.

Defactinib hydrochloride

Defactinib hydrochloride is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.

GSK2256098

GSK2256098 is a potent, selective, reversible, and ATP competitive FAK kinase inhibitor with apparent Ki of 0.4 nM.

Y15

Y15 is a novel small molecule FAK phosphorylation inhibitor; specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK.

PF-431396

PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BI-4464, BI4464 supplier, FAK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.