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Solanesol

Cat. No. M9256
Solanesol Structure
Synonym:

Nonaisoprenol, Betulanonaprenol

Size Price Availability Quantity
100mg USD 70  USD70 In stock
200mg USD 120  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Solanesol mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants. Solanesol binds at ATP binding site and inhibit the phosphorylation of Focal Adhesion Kinase (FAK). Solanesol upregulates HO-1 and Hsp70 expression in L02 cells which activate Nrf2 and HSF1. It induces Nrf2 by enhancement of Keap1 interaction with Hsp90. Solanesol-activated HSF1 is involved in chaperones interaction.

Protocol
Cell Experiment
Cell lines human hepatic cell L02
Preparation method Cell viability is determined by MTT assays.
Cells are seeded into 96-well plates (5 × 104 cells/well) 24 h before treatment. The cells are then treated with various concentrations of solanesol followed by incubating with 5 mg/ml of MTT working solution for 4 h at 37 °C. After being treated with 100 μL of DMSO to dissolve the crystals, the cells are detected under an Microplate Reader to measure the absorbance at 570 nm.
Concentrations 10, 50, 100, 250, 500, 1000 μM
Incubation time 12 h
Animal Experiment
Animal models Male albino rats
Formulation Gelling agent Carbopol-934
Dosages 0.2 g of gel containing solanesol (1 % w/v)
Administration applied to the plantar surface of the right hind paw by gently rubbing with the index finger
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 631.07
Formula C45H74O
CAS Number 13190-97-1
Purity >98%
Solubility Soluble in Chloroform
Storage at -20°C
References

[1] Yao X, et al. Food Funct. Solanesol induces the expression of heme oxygenase-1 via p38 and Akt and suppresses the production of proinflammatory cytokines in RAW264.7 cells.

[2] Yao X, et al. Toxicol In Vitro. Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Solanesol, Nonaisoprenol, Betulanonaprenol supplier, FAK, inhibitors

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