About 28 results found for searched term "HMG-CoA Reductase" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42445 | HMG-CoA Reductase-IN-1 | HMG-CoA Reductase |
| HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. | ||
| M2126 | Fluvastatin sodium | HMG-CoA Reductase |
| XU 62-320 | ||
| Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. | ||
| M2846 | Mevastatin | Others |
| Compactin; ML236B | ||
| Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. | ||
| M2956 | Pravastatin sodium | HMG-CoA Reductase |
| CS-514 sodium | ||
| Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. | ||
| M3497 | Simvastatin (MK 733) | Autophagy |
| MK 733; MK-0733 | ||
| Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. | ||
| M1575 | Lovastatin | HMG-CoA Reductase |
| MK-803; Mevinolin | ||
| Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). | ||
| M5430 | Atorvastatin hemicalcium | HMG-CoA Reductase |
| CI-981; Atorvastatin Calcium | ||
| Atorvastatin hemicalcium (CI-981) is an orally active inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. | ||
| M8184 | S-2E | Acetyl-CoA Carboxylase |
| S2E | ||
| S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. | ||
| M9116 | Atorvastatin | HMG-CoA Reductase |
| Lipilou; Tozalip; Torvast; Cardyl | ||
| Atorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. | ||
| M10864 | Nicodicosapent | Others |
| Nicodicosapent is a fatty acid niacin conjugate that inhibits the activity of sterol regulatory element binding proteins (SREBP) and the activity of proteins that regulate cholesterol metabolism such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1. | ||
| M17844 | Lanosterol | Metabolite/Endogenous Metabolite |
| Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases. | ||
| M20528 | Pravastatin | HMG-CoA Reductase |
| Pravastatin is an HMG-CoA reductase (HMGCR) inhibitor that inhibits sterol synthesis with an IC50 of 5.6 μM. | ||
| M21341 | β-Muricholic Acid | Metabolite/Endogenous Metabolite |
| β-Muricholic acid is a murine-specific primary bile acid. Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet. Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones. | ||
| M27634 | Simvastatin hydroxy acid sodium | HMG-CoA Reductase |
| Tenivastatin sodium; Simvastatin Impurity A sodium | ||
| Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | ||
| M27949 | Simvastatin acid | HMG-CoA Reductase |
| Tenivastatin | ||
| Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin, is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | ||
| M28329 | Simvastatin acid ammonium | HMG-CoA Reductase |
| Tenivastatin ammonium | ||
| Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | ||
| M28423 | Cerivastatin sodium | HMG-CoA Reductase |
| Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect. | ||
| M28490 | Cerivastatin | HMG-CoA Reductase |
| Cerivastatin is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin reduces low-density lipoprotein cholesterol levels. Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect. | ||
| M28512 | Rosuvastatin Sodium | HMG-CoA Reductase |
| ZD 4522 Sodium; X-Plended Sodium; Crestor Sodium | ||
| Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels. | ||
| M30577 | Lovastatin hydroxy acid sodium | HMG-CoA Reductase |
| Mevinolinic acid sodium | ||
| Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM. | ||
| M31157 | 2-Hydroxy atorvastatin calcium salt | HMG-CoA Reductase |
| 2-Hydroxy atorvastatin calcium salt is the hydroxyl metabolite of Atorvastatin calcium salt, an inhibitor of HMG-CoA reductase that inhibits cholesterol production with an IC50 value of 8 nM. | ||
| M31158 | 4-Hydroxy atorvastatin calcium salt | HMG-CoA Reductase |
| para-Hydroxy atorvastatin calcium salt | ||
| 4-Hydroxy atorvastatin calcium salt is the hydroxyl metabolite of Atorvastatin calcium salt, an inhibitor of HMG-CoA reductase that inhibits cholesterol production with an IC50 value of 8 nM. | ||
| M40808 | β-Amyrin acetate | Anti-infection |
| β-Amyrin acetate is a triterpenoid natural product that localizes to HMG CoA reductase and inhibits its activity, with potent anti-inflammatory, anti-fungal, anti-diabetic, and anti-hyperlipidemic activities. | ||
| M40866 | Meglutol | HMG-CoA Reductase |
| Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid | ||
| Meglutol is an antilipidemic agent that lowers cholesterol, triglycerides, serum beta-lipoproteins, and phospholipids, and inhibits the activity of the rate-limiting enzyme of cholesterol biosynthesis, HMG-CoA reductase. | ||
| M42442 | Bemfivastatin | HMG-CoA Reductase |
| Bemfivastatin (PPD 10558) is an orally active, HMG-CoA Reductase (HMGCR) inhibitor, also known as Statin. | ||
| M42444 | Ganomycin I | HMG-CoA Reductase |
| Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. | ||
| M45124 | Fluvastatin | HMG-CoA Reductase |
| XU 62-320 free acid | ||
| Fluvastatin is the first fully synthesized, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.Fluvastatin protects vascular smooth muscle cells from oxidative stress through an Nrf2-dependent antioxidant pathway. | ||
| M56702 | Dalvastatin | HMG-CoA Reductase |
| Dalvastatin (RG-12561) inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis. | ||
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