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Meglutol is an antilipidemic agent that lowers cholesterol, triglycerides, serum beta-lipoproteins, and phospholipids, and inhibits the activity of the rate-limiting enzyme of cholesterol biosynthesis, HMG-CoA reductase.
| Molecular Weight | 162.14 |
| Formula | C6H10O5 |
| CAS Number | 503-49-1 |
| Form | Solid |
| Solubility (25°C) | DMSO > 250 mg/mL |
| Storage | -20°C |
[2] Dylan E Jones et al. Clin Chim Acta. 3-Methylglutaric acid in energy metabolism
[3] I Yoshida. Ryoikibetsu Shokogun Shirizu. [3-Hydroxy-3-methylglutaryl-CoA-lyase deficiency]
[4] T Lerman-Sagie. Pediatr Neurol. Behr syndrome
[5] C L Greene et al. J Neurogenet. 3-Hydroxy-3-methylglutaric aciduria
| Related HMG-CoA Reductase Products |
|---|
| Mevastatin
Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
| Clinofibrate
Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood. |
| Cerivastatin sodium
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect. |
| 2-Hydroxy atorvastatin calcium salt
2-Hydroxy atorvastatin calcium salt is the hydroxyl metabolite of Atorvastatin calcium salt, an inhibitor of HMG-CoA reductase that inhibits cholesterol production with an IC50 value of 8 nM. |
| 4-Hydroxy atorvastatin calcium salt
4-Hydroxy atorvastatin calcium salt is the hydroxyl metabolite of Atorvastatin calcium salt, an inhibitor of HMG-CoA reductase that inhibits cholesterol production with an IC50 value of 8 nM. |
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