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Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases. Lanosterol is a precursor of meiosis-activating sterols in the cholesterol biosynthetic pathway and induces a physiological signal that instructs the oocyte to reinitiate meiosis.
| Molecular Weight | 426.72 |
| Formula | C30H50O |
| CAS Number | 79-63-0 |
| Solubility (25°C) | DMSO 5 mg/mL Ethanol 3 mg/mL |
| Storage | Powder -20°C |
[1] Xianwen Long, et al. J Am Chem Soc. Bioinspired Synthesis of Spirochensilide A from Lanosterol
[2] Hong Zhou, et al. ACS Chem Neurosci. Lanosterol Disrupts the Aggregation of Amyloid-β Peptides
[4] Ling Zhao, et al. Nature. Lanosterol reverses protein aggregation in cataracts
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