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Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases. Lanosterol is a precursor of meiosis-activating sterols in the cholesterol biosynthetic pathway and induces a physiological signal that instructs the oocyte to reinitiate meiosis.
| Molecular Weight | 426.72 |
| Formula | C30H50O |
| CAS Number | 79-63-0 |
| Solubility (25°C) | DMSO 5 mg/mL Ethanol 3 mg/mL |
| Storage | Powder -20°C |
[1] Xianwen Long, et al. J Am Chem Soc. Bioinspired Synthesis of Spirochensilide A from Lanosterol
[2] Hong Zhou, et al. ACS Chem Neurosci. Lanosterol Disrupts the Aggregation of Amyloid-β Peptides
[4] Ling Zhao, et al. Nature. Lanosterol reverses protein aggregation in cataracts
| Related Metabolite/Endogenous Metabolite Products |
|---|
| p-Cresol glucuronide
p-Cresol glucuronide is a metabolite of p-cresol, it is a prototype protein-bound uremic toxin. |
| Oleamide
Oleamide is an endogenous fatty acid amide. |
| Deoxycarnitine chloride
Deoxycarnitine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota. |
| Monobutyl phthalate
Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant. |
| Testosterone sulfate (pyridinium)
Testosterone sulfate pyridinium is a Testosterone sulfate with a pyridinium. Testosterone sulfate is the metabolite of Testosterone. |
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