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Pravastatin

Cat. No. M20528
Pravastatin Structure
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Biological Activity

Pravastatin is an HMG-CoA reductase (HMGCR) inhibitor that inhibits sterol synthesis with an IC50 of 5.6 μM.

Chemical Information
Molecular Weight 424.53
Formula C23H36O7
CAS Number 81093-37-0
Solubility (25°C) DMSO 85 mg/mL
Water 85 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zahid Ijaz Tarar, et al. J Investig Med High Impact Case Rep. Pravastatin-Induced Acute Pancreatitis: A Case Report and Literature Review

[2] Maged M Costantine, et al. Am J Obstet Gynecol. A randomized pilot clinical trial of pravastatin versus placebo in pregnant patients at high risk of preeclampsia

[3] Wanda Gajzlerska-Majewska, et al. J Perinat Med. Is pravastatin a milestone in the prevention and treatment of preeclampsia?

[4] Enrique Esteve-Valverde, et al. Obstet Gynecol Surv. Pravastatin for Preventing and Treating Preeclampsia: A Systematic Review

[5] Abdullah A Al-Badr, et al. Profiles Drug Subst Excip Relat Methodol. Pravastatin sodium

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Keywords: Pravastatin supplier, HMG-CoA Reductase, inhibitors, activators


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