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Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin, is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
| Molecular Weight | 436.58 |
| Formula | C25H40O6 |
| CAS Number | 121009-77-6 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[5] A Kalliokoski, et al. Br J Pharmacol. Impact of OATP transporters on pharmacokinetics
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