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β-Muricholic Acid

Cat. No. M21341

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β-Muricholic Acid Structure
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1mg USD 145  USD145 In stock
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Quality Control & Documentation
Biological Activity

β-Muricholic acid is a murine-specific primary bile acid. Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet. Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.

Chemical Information
Molecular Weight 408.58
Formula C24H40O5
CAS Number 2393-59-1
Solubility (25°C) Soluble in DMSO
Storage 2-8°C
References

[1] Pan Huang, et al. Front Nutr. NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota

[2] Xiaojiao Zheng, et al. Cell Metab. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism

[3] Ting Fu, et al. Cell. FXR Regulates Intestinal Cancer Stem Cell Proliferation

[4] Frank J Gonzalez, et al. Gastroenterology. An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease

[5] Sama I Sayin, et al. Cell Metab. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

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