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β-Muricholic acid is a murine-specific primary bile acid. Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet. Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.
| Molecular Weight | 408.58 |
| Formula | C24H40O5 |
| CAS Number | 2393-59-1 |
| Solubility (25°C) | Soluble in DMSO |
| Storage | 2-8°C |
[3] Ting Fu, et al. Cell. FXR Regulates Intestinal Cancer Stem Cell Proliferation
| Related Metabolite/Endogenous Metabolite Products |
|---|
| 3-Methyl-2-oxovaleric acid
3-methyl-2-oxovaleric acid (KMV) is a 2-oxoglutarate dehydrogenase (OGDH) inhibitor. 3-Methyl-2-oxovaleric acid is also a neurotoxin, an acidogen, and a metabotoxin. 3-Methyl-2-oxovaleric acid is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. |
| Succinyl-Coenzyme A sodium
Succinyl-Coenzyme A (SCoA) sodium is an intermediate of the citric acid cycle. Succinyl-Coenzyme A sodium can be converted to succinic acid and can also combines with glycine to form δ-ALA to synthesize porphyrins (heme). Succinyl-Coenzyme A (SCoA) is also an inhibitor of TCA cycle. |
| AFMK
AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. |
| DL-AP3
DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. |
| SY-640
SY-640 is an Acetamide derivative and has potent hepatoprotective effect. |
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