About 30 results found for searched term "HI-6" (0.037 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1859 | RepSox | ALK |
| ALK5 Inhibitor II; E-616452; SJN 2511 | ||
| RepSox (ALK5 Inhibitor II) is a potent and ATP-competitive inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). | ||
| M1863 | RAF265 | Raf |
| CHIR-265 | ||
| RAF265 is a novel, orally bioavailable dual inhibitor of RAF kinase and VEGFR2. | ||
| M2114 | GSK126 | EZH2 |
| EZH2 inhibitor; GSK2816126A | ||
| GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. | ||
| M2659 | E-64 | Autophagy |
| Proteinase inhibitor E 64 | ||
| E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. | ||
| M3258 | Thioguanine | DNA/RNA Synthesis |
| 6-Thioguanine; 6-TG; 2-Amino-6-mercaptopurine; 2-Amino-6-purinethiol | ||
| Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients. | ||
| M4786 | Aristolochic acid A | NF-κB |
| Aristolochic acid I; TR 1736 | ||
| Aristolochic acid A (Aristolochic acid I; TR 1736) is the principal component of the plant extract Aristolochic Acids, found in Aristolochia and Asarum herbs. Aristolochic acid A significantly decreased activator protein 1 (AP-1) and NF-κB activity. Aristolochic acid A reduces the expression of bladder cancer-associated BLCAP gene in human cells. | ||
| M6278 | Epothilone D | Microtubule |
| 12,13-Desoxyepothilone B; Desoxyepothilone B; KOS 862 | ||
| Epothilone D is a potent microtubule stabilizer. | ||
| M6804 | IBMX | PDE |
| IMX; Isobutylmethylxanthine; Methylisobutylxanthine; NSC165960; SC2964; 3-isobutyl-1-methylxanthine | ||
| IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. | ||
| M6892 | LAP | Others |
| Lithium phenyl-2,4,6-trimethylbenzoylphosphinate | ||
| LAP (Lithium phenyl-2,4,6-trimethylbenzoylphosphinate) is a water soluble, cytocompatible, Type I photoinitiator for use in the polymerization of hydrogels or other polymeric materials. This photoinitator is preferred over Irgacure 2959 for biological applications due to its increased water solubility, increased polymerization rates with 365 nm light, and absorbance at 400 nm allowing for polymerization with visible light. | ||
| M8206 | PDI inhibitor 16F16 | Others |
| 16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. | ||
| M8262 | HI-6 | AChR/AChE |
| Asoxime dichloride | ||
| Asoxime dichloride (HI-6) is an efficient oxime cholinesterase reactivator that is used as an antidote for organophosphates (Ops) exposure. | ||
| M8459 | TRAF-STOP inhibitor 6877002 | Others |
| CD40-TRAF6 signaling inhibitor | ||
| TRAF-STOP inhibitor 6877002 is a small molecule that binds to TRAF6, blocking interactions with CD40. | ||
| M9364 | Recombinant human IL-6 (CHO-expressed) | Cytokines and Growth Factors |
| Interleukin-6; rhIL-6 | ||
| Recombinant Human IL-6 is an interleukin that in humans is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine. | ||
| M9642 | EGFR inhibitor 324674 | EGFR/HER2 |
| EGFR-IN-12 | ||
| EGFR inhibitor 324674 is a cell permeable, potent and selective EGFR inhibitor with IC50 of 21 nM. | ||
| M11041 | WEHI-9625 | VDAC |
| WEHI-9625 is a first-in-class tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX. | ||
| M11197 | Recombinant Mouse IL-13 Protein (CHO, C-His) | Cytokines and Growth Factors |
| rMuIL-13, His; P600 | ||
| Recombinant Mouse IL-13 Protein is an immunoregulatory cytokine belonging to the IL-4/IL-13 family, a multifunctional cytokine whose main role is to reduce the inflammatory response. | ||
| M13761 | 5(6)-FITC | Fluorescent Dye |
| Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers | ||
| 5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of fluorescein dye that has wide-ranging applications as a label for antibodies and other probes, for use in fluorescence microscopy, flow cytometry and immunofluorescence-based assays such as Western blotting and ELISA. | ||
| M14255 | IK1 inhibitor PA-6 | Potassium Channel |
| PA-6 | ||
| IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. | ||
| M14905 | PKA Inhibitor Fragment (6-22) amide TFA | PKA |
| PKI-(6-22)-amide TFA | ||
| PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse low-level morphine antinociceptive tolerance in mice. | ||
| M15990 | 5-Hydroxy-4-methoxycanthin-6-one | Alkaloids |
| 5-Hydroxy-4-methoxycanthin-6-one | ||
| M16018 | 5-Methoxycanthin-6-one | Alkaloids |
| 5-Methoxycanthin-6-one | ||
| M16019 | 1-Hydroxycanthin-6-one | Alkaloids |
| 1-Hydroxycanthin-6-one | ||
| M16105 | Canthin-6-one | Alkaloids |
| Canthin-6-one | ||
| M18102 | Aldehydoisoophiopogonanone A, 6- | Others |
| Aldehydoisoophiopogonanone A, 6- | ||
| M18219 | 4,5-dimethoxycanthin-6-one | Others |
| 4,5-dimethoxycanthin-6-one | ||
| M18308 | 11-Hydroxycanthin-6-one | Others |
| 11-Hydroxycanthin-6-one | ||
| M20510 | Chicago Sky Blue 6B | Others |
| A potent inhibitor of L-glutamate uptake via glutamate transporter (EAAT) | ||
| M20596 | K-Ras(G12C) inhibitor 6 | ROCK |
| K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C). | ||
| M20680 | IRAK inhibitor 6 | IRAK |
| IRAK inhibitor 6 is a selective Interleukin-1 receptor-associated kinase 4(IRAK4) inhibitor with IC50 of 0.16 μM. | ||
| M20707 | RK 24466 | Src-bcr-Abl |
| KIN 001-51, Lck inhibitor C 8863, C8863 | ||
| RK-24466 (KIN 001-51) is a potent and selective inhibitor of Lck that inhibits two constructs of the human lck kinase, lck (64-509) and lckcd with IC50 of < 0.001 μM and 0.002 μM, respectively. | ||
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