Recombinant Human IL-6 is an interleukin that in humans is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, as well as nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction, to be released to the blood stream to help break down fats and improve insulin resistance.
The ED50 is <0.1 ng/mL as measured by murine 7TD1 cells, corresponding to a specific activity of 5 × 107 units/mg.
| Solubility (25°C) | Water Saline PBS |
| Storage | 2-8°C, dry, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. |
| Recombinant Human EpCAM/Trop-1 (Mammalian, C-Fc)
Epithelial Cell Adhesion Molecule (EpCAM) is a signal type I transmembrane glycoprotein. EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells. |
| Recombinant Human IL-36 gamma/IL-1 F9 Protein (E. coli, aa 18-169, His Tag)
The recombinant human IL1F9 consists of 168 amino acids and predicts a molecular mass of 19.1 KDa. A DNA sequence encoding the mature form of human IL1F9 (Ser18-Asp169) was expressed with a polyhistide tag at the N-terminus. |
| Recombinant Human IL-36 gamma/IL-1 F9 Protein (E. coli)
The recombinant human IL1F9 consisting of 169 amino acids and has a calculated molecular mass of 18.9 kDa. A DNA sequence encoding the human IL-1F9 isoform 1 (Met 1-Asp 169) was expressed. |
| Recombinant Human APOL1 Protein (Baculovirus-Insect, C-His)
APOL1, also known as apolipoprotein L1, belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. |
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