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Recombinant Mouse IL-13 Protein (CHO, His)

Cat. No. M11197
Recombinant Mouse IL-13 Protein (CHO, His) Structure
Synonym:

rMuIL-13, His; P600

Size Price Availability Quantity
10ug USD 220  USD220 In stock
50ug USD 720  USD720 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Mouse IL-13 Protein (CHO, His) is an important cytokine derived from CHO cells, a multifunctional cytokine whose main role is to reduce the inflammatory response.

Chemical Information
Solubility (25°C) Reconstituted in ddH2O or PBS at 100 μg/ml
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sreeja Roy, et al. Sci Rep. Unique IL-13Rα2/STAT3 mediated IL-13 regulation detected in lung conventional dendritic cells, 24 h post viral vector vaccination

[2] Kai J Rogers, et al. PLoS Negl Trop Dis. IL-4/IL-13 polarization of macrophages enhances Ebola virus glycoprotein-dependent infection

[3] Dylan J Wodsedalek, et al. Am J Physiol Heart Circ Physiol. IL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration

[4] Akiko Suzuki, et al. Cytokine. Targeting of IL-4 and IL-13 receptors for cancer therapy

[5] Dong Li, et al. J Allergy Clin Immunol. IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice

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Keywords: Recombinant Mouse IL-13 Protein (CHO, His), rMuIL-13, His; P600 supplier, Recombinant Proteins, inhibitors, activators


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