About 30 results found for searched term "Gli" (0.008 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1799 | Imatinib Mesylate | Src-bcr-Abl |
| Gleevec, Glivec, CGP-57148B, STI-571 | ||
| Imatinib Mesylate is a Bcr-Abl tyrosine kinase inhibitor, with IC50 values of 2.9 and 3.9 μM for the inhibition of T-cell proliferation stimulated by PHA and DCs respectively. | ||
| M1894 | Rosiglitazone | PPAR |
| BRL 49653 | ||
| Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50=60 nM, Kd=40 nM). Rosiglitazone is an TRPC5 activator (EC50=30 μM) and TRPM3 inhibitor. | ||
| M1937 | Dapagliflozin | SGLT |
| BMS-512148 | ||
| Dapagliflozin (BMS-512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). | ||
| M1967 | Sitagliptin phosphate monohydrate | Dipeptidyl Peptidase |
| MK-0431, Januvia | ||
| Sitagliptin phosphate (MK-0431) is a potent inhibitor of dipeptidyl peptidase-4 (DPP-4) with IC50 of 19 nM. | ||
| M2002 | Canagliflozin | SGLT |
| JNJ 24831754ZAE; JNJ 28431754; JNJ 28431754AAA; TA 7284 | ||
| Canagliflozin is a potent, selective sodium glucose co-transporter 2 inhibitor. | ||
| M2038 | Rosiglitazone maleate | PPAR |
| Avandia | ||
| Rosiglitazone maleate (Avandia) is a potent and selective PPARγ ligand that binds to the PPARγ ligand-binding domain with a Kd value of 43 nM. | ||
| M2054 | Fasiglifam (TAK-875) Hemihydrate | GPR/FFAR |
| Fasiglifam Hemihydrate; TAK875 hydrate | ||
| Fasiglifam (TAK-875) Hemihydrate is a novel, orally available, selective GPR40 agonist. | ||
| M2341 | Trelagliptin | Dipeptidyl Peptidase |
| SYR-472 | ||
| Trelagliptin (SYR-472) is a novel once-weekly oral DPP-4 inhibitor for type 2 diabetes. | ||
| M2374 | Alogliptin | Dipeptidyl Peptidase |
| SYR-322 | ||
| Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. | ||
| M2667 | Empagliflozin | SGLT |
| BI 10773 | ||
| Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. | ||
| M2724 | Gliquidone | Potassium Channel |
| Glurenorm | ||
| Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. | ||
| M2814 | Linagliptin | Dipeptidyl Peptidase |
| BI-1356 | ||
| Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. | ||
| M2870 | MSDC-0160 | Others |
| Mitoglitazone; CAY10415 | ||
| MSDC 0160 (Mitoglitazone) is an insulin sensitizer that regulates the mitochondrial target of thiazolidinedione (mTOT) and a regulator of mitochondrial pyruvate vector (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has potential for use in Alzheimer's disease. | ||
| M3119 | Vildagliptin | Dipeptidyl Peptidase |
| LAF237; NVP-LAF 237 | ||
| Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity. | ||
| M3122 | Voglibose | Glucosidase |
| Voglibose is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia. | ||
| M3283 | Pioglitazone | PPAR |
| U 72107 | ||
| Pioglitazone (U 72107) is a selective peroxisome proliferator-activated receptor gamma stimulator. | ||
| M3399 | Gliclazide | Potassium Channel |
| S1702; SE1702 | ||
| Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. | ||
| M3415 | Nateglinide | Potassium Channel |
| A-4166; Senaglinide | ||
| Nateglinide is an orally active, short-acting insulin-releasing compound that is also an inhibitor of DPP IV. Nateglinide inhibits ATP-sensitive K+ channels in islet β cells. Nateglinide is available for the study of type 2 diabetes mellitus (non-insulin-dependent). | ||
| M3435 | Saxagliptin | Dipeptidyl Peptidase |
| BMS-477118 | ||
| Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active inhibitor of dipeptidyl peptidase 4 (DPP-4) (Ki = 0.6-1.3 nM). Saxagliptin can be used in type 2 diabetes studies. | ||
| M3505 | Glipizide | Potassium Channel |
| CP 28720; K 4024 | ||
| Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. | ||
| M3547 | Glibenclamide | Others |
| Glyburide; RP-1127; BIIB093 | ||
| Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). | ||
| M3562 | LY2608204 | Glucokinase (GK) |
| Globalagliatin | ||
| LY2608204 activates glucokinase (GK) with EC50 of 42 nM. | ||
| M3714 | Repaglinide | Potassium Channel |
| AG-EE, 623ZW | ||
| Repaglinide is an insulin secretagogue used in type 2 diabetes. | ||
| M3957 | Mitiglinide calcium | Potassium Channel |
| KAD-1229,S21403 | ||
| Mitiglinide (KAD 1229, S 21403), a derivative of benzysuccinic acid, is a potassium channel antagonist developed with Kissei for the study of type 2 diabetes. | ||
| M4936 | Omarigliptin | Dipeptidyl Peptidase |
| MK-3102 | ||
| Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over all proteases tested (IC50 > 67 _mu_M). | ||
| M4968 | Mitiglinide calcium hydrate | Potassium Channel |
| KAD-1229 calcium hydrate; S-21403 calcium hydrate | ||
| Miglinide calcium hydrate is a compound used to study type 2 diabetes mellitus. It is a highly selective KATP channel antagonist. | ||
| M5150 | Glimepiride | PPAR |
| Glimperide; HOE-490; Amaryl | ||
| Glimepiride (Glimperide; HOE-490) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg. | ||
| M2407 | Atglistatin | ATGL |
| Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases. | ||
| M5171 | Troglitazone (CS-045) | PPAR |
| Rezulin, Romglizone, Prelay, CS-045, CS045, CS 045, Romozin | ||
| Troglitazone is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth. | ||
| M5249 | Sotagliflozin | SGLT |
| LX-4211; LP-802034 | ||
| Sotagliflozin (LX-4211) is an orally active, first-in-class dual SGLT1/2 inhibitor with IC50s of 36 nM and 1.8 nM, respectively, and is used in studies related to type 1 diabetes and heart failure. | ||
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