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Alogliptin

Cat. No. M2374
Alogliptin Structure
Synonym:

SYR-322

Size Price Availability Quantity
5mg USD 125  USD125 In stock
10mg USD 180  USD180 In stock
25mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

Chemical Information
Molecular Weight 339.39
Formula C18H21N5O2
CAS Number 850649-61-5
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Devjani Ganesan, et al. Alogliptin-Associated Pancreatitis

[2] No authors listed. Alogliptin

[3] No authors listed. Alogliptin

[4] Jamie M. Terrell, et al. Alogliptin

[5] William B White, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes

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Keywords: Alogliptin, SYR-322 supplier, DPP, inhibitors, activators


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