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Alogliptin

Cat. No. M2374
Alogliptin Structure
Synonym:

SYR-322

Size Price Availability Quantity
5mg USD 125  USD125 In stock
10mg USD 180  USD180 In stock
25mg USD 350  USD350 In stock
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Quality Control
Biological Activity

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 339.39
Formula C18H21N5O2
CAS Number 850649-61-5
Purity >98%
Solubility DMSO 50 mg/mL
Storage at -20°C
References

[1] Devjani Ganesan, et al. Alogliptin-Associated Pancreatitis

[2] No authors listed. Alogliptin

[3] No authors listed. Alogliptin

[4] Jamie M. Terrell, et al. Alogliptin

[5] William B White, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes

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Keywords: Alogliptin, SYR-322 supplier, DPP-4, inhibitors

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