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Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.
Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice. Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats.
Pharmacology. 2023;108(2):166-175.
DPP4 Inhibitor Sitagliptin Reduces Inflammatory Responses and Mast Cell Activation in Allergic Rhinitis
Vildagliptin purchased from AbMole
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Animal models | Obese male Zucker rats |
Formulation | 0.5% carboxymethylcellulose (CMC) and 0.2% Tween 80 |
Dosages | 10 μmol/kg |
Administration | Orally administrated at a single dose |
Molecular Weight | 303.4 |
Formula | C17H25N3O2 |
CAS Number | 274901-16-5 |
Solubility (25°C) | Water 45 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Michał Wiciński, et al. Vasculoprotective Effects of Vildagliptin. Focus on Atherogenesis
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Products are for research use only. Not for human use. We do not sell to patients.
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