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Vildagliptin

Cat. No. M3119
Vildagliptin  Structure
Synonym:

LAF237; NVP-LAF 237

Size Price Availability Quantity
10mg USD 75  USD75 In stock
25mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Obese male Zucker rats
Formulation 0.5% carboxymethylcellulose (CMC) and 0.2% Tween 80
Dosages 10 μmol/kg
Administration Orally administrated at a single dose
Chemical Information
Molecular Weight 303.4
Formula C17H25N3O2
CAS Number 274901-16-5
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Michał Wiciński, et al. Vasculoprotective Effects of Vildagliptin. Focus on Atherogenesis

[2] David R Matthews, et al. Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomised, double-blind trial

[3] Toshio Suzuki, et al. Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition

[4] Yasuhiko Iwamoto. Vildagliptin

[5] Sheridan Henness, et al. Vildagliptin

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  Catalog
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Keywords: Vildagliptin , LAF237; NVP-LAF 237 supplier, DPP, inhibitors, activators


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