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Vildagliptin

Cat. No. M3119

All AbMole products are for research use only, cannot be used for human consumption.

Vildagliptin  Structure
Synonym:

LAF237; NVP-LAF 237

Size Price Availability Quantity
5mg USD 35  USD35 In stock
10mg USD 55  USD55 In stock
25mg USD 85  USD85 In stock
50mg USD 115  USD115 In stock
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Quality Control & Documentation
Biological Activity

Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.

Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice. Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats.

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Obese male Zucker rats
Formulation 0.5% carboxymethylcellulose (CMC) and 0.2% Tween 80
Dosages 10 μmol/kg
Administration Orally administrated at a single dose
Chemical Information
Molecular Weight 303.4
Formula C17H25N3O2
CAS Number 274901-16-5
Solubility (25°C) Water 45 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Michał Wiciński, et al. Vasculoprotective Effects of Vildagliptin. Focus on Atherogenesis

[2] David R Matthews, et al. Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomised, double-blind trial

[3] Toshio Suzuki, et al. Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition

[4] Yasuhiko Iwamoto. Vildagliptin

[5] Sheridan Henness, et al. Vildagliptin

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Keywords: Vildagliptin , LAF237; NVP-LAF 237 supplier, Dipeptidyl Peptidase, inhibitors, activators

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