Trelagliptin (SYR-472) is a highly selective once-weekly oral dipeptidyl peptidase-4 (DPP-4) inhibitor for type 2 diabetes. Trelagliptin (SYR-472) treatment produced clinically and statistically significant improvements in glycaemic control in patients with type 2 diabetes.
DPP4 Inhibitor Sitagliptin Reduces Inflammatory Responses and Mast Cell Activation in Allergic Rhinitis
Trelagliptin purchased from AbMole
|Solubility (25°C)||DMSO 60 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Inagaki N, et al. Lancet Diabetes Endocrinol. SYR-472, a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial.
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