About 31 results found for searched term "Ex26" (0.101 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8611 | Ex26 | S1P Receptor |
| Ex26 is a peripherally-restricted biphenylcarboxamide derivative that acts as a highly potent and subtype-selective S1P1 antagonist (IC50 = 0.93 nM against S1PR1 and >3.1 μM against S1PR2/3/4/5). | ||
| M51308 | Connexin mimetic peptide 40, 37GAP26 | Others |
| Connexin mimetic peptide 40,37GAP26 is a biological active peptide. | ||
| M3983 | Puerarin | 5-HT Receptor |
| Puerarin is a 5-HT2C receptor antagonist. Puerarin inhibits the expression of LPS-induced iNOS, COX-2 and CRP proteins and also suppresses their mRNAs from RT-PCR experiments in RAW264.7 cells. | ||
| M4520 | (+)-Corydaline | AChR/AChE |
| (+)-Corydaline; Corydalin | ||
| Corydaline ((+) -corydaline) is an isoquinoline alkaloid extracted from Corydalis Yanhusuo. It is an inhibitor of AChE with IC50 of 226 µM. Corydaline is a μ-opioid receptor agonist (Ki = 1.23 µM) that inhibits the replication of enterovirus 71 (EV71) (IC50 = 25.23 µM). Corydaline has anti-angiogenesis, anti-allergy, gastric emptying and anti-nociception effects. | ||
| M6466 | AS 1269574 | GPR/FFAR |
| AS1269574 is a potent, orally active GPR119 agonist with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates the TRPA1 cation channel and stimulates glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induced pancreatic β cells to secrete glucose-dependent insulin only under high glucose conditions. AS1269574 has potential for type 2 diabetes research. | ||
| M8679 | IMR-1 | Notch |
| IMR-1 is a first-in-class, cell-permeable inhibitor of the Notch transcription activation complex, with an IC50 of 26 μM. IMR-1 prevents Maml1 from recruiting to the Notch ternary complex (NTC) in chromatin, inhibits transcription of Notch target genes, and has antitumor activity. | ||
| M9042 | Prexasertib dihydrochloride | Checkpoint |
| LY2606368 Prexasertib HCl | ||
| Prexasertib (LY2606368) is a substrate ATP competitively selective inhibitor of CHK1 and CHK2 with IC50 values of <1 nM and 8 nM against CHK1 and CHK2, respectively. | ||
| M9710 | Roquinimex | TNF Receptor |
| LS2616; FCF89; Linomide; ABR212616 | ||
| Roquinimex (LS2616; FCF89) is a quinoline-3-carboxamide with potential antineoplastic activity, which increases NK cell activity and macrophage cytotoxicity. | ||
| M13622 | Prexasertib | Checkpoint |
| LY2606368 | ||
| Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. | ||
| M13623 | Prexasertib dimesylate | Checkpoint |
| LY2606368 dimesylate | ||
| Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. | ||
| M15033 | Recombinant Mouse IL-17A (CHO) | Cytokines and Growth Factors |
| IL17A, CTLA-8 | ||
| Interleukin-17a (also known as CTLA-8) is a pleiotropic cytokine expressed by T cells and has a high degree of homology to the protein encoded by the ORF13 gene of herpetic virus squirrel monkey. Protein structure: IL-17A (ALA26-ALA158), Accession # Q62386. | ||
| M15015 | Recombinant Human Carbonic Anhydrase 1/CA1 (E.coli,C-6His) | Cytokines and Growth Factors |
| Carbonate Dehydratase I; Carbonic Anhydrase B | ||
| The recombinant human Carbonic Anhydrase 1/CA1 protein was produced by our escherichia coli expression system, and the target gene encoding ALA2-PHE261 was expressed at the C-terminal as 6His marker. Accession # : P00915. | ||
| M15080 | Recombinant Human OSM (E.coli, N-6His) | Cytokines and Growth Factors |
| Oncostatin-M; OSM | ||
| Recombinant human Oncostatin M is produced by escherichia coli expression system, and the target gene encoding AlA26-ARG221 was expressed at the N-terminal with 6His marker. Measured by the dose-dependent stimulation of TF-1 cells. The ED50 for this effect is 0.2-1 ng/ml. | ||
| M15084 | Recombinant Mouse Sonic Hedgehog/Shh (E.coli) | Cytokines and Growth Factors |
| Sonic Hedgehog Protein; SHH; HHG-1; SHH | ||
| Recombinant mouse Sonic Hedgehog gene was prepared by escherichia coli expression system and the target gene encoding Cys25-Gly198 was expressed. Accession # : Q62226. | ||
| M15093 | Recombinant Human EpCAM/Trop1 (Expi293, C-His) | Cytokines and Growth Factors |
| CD326 antigen; CD326; EGP; EGP-2 | ||
| Epithelial Cellular Adhesion Molecule (EpCAM), also known as KS1/4, gp40, GA733-2, 17-1A, and TROP‑1, is a 40 kDa transmembrane glycoprotein that consists of a 242 amino acid (aa) extracellular domain with two EGF‑like repeats, a 23 aa transmembrane segment, and a 26 aa cytoplasmic domain. | ||
| M18925 | Dactylorhin A | Others |
| Dactylorhin A is a succinate derivative ester isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells. | ||
| M19411 | Cafestol | ERK |
| Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activatio䲧瓰Ỵ瓱��㧀 | ||
| M21413 | Inflexuside B | NO Synthase |
| Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages | ||
| M21570 | Recombinant Human CD3E (HEK293, C-6His) | Cytokines and Growth Factors |
| T-Cell Surface Glycoprotein CD3 Epsilon Chain | ||
| The recombinant human t cell surface glycoprotein CD3 Epsilon chain is produced by mammalian expression systems, and the target gene encoding Asp23-Asp126 is expressed by 6His tag at the C-terminal. Protein number: P07766. | ||
| M21572 | Recombinant Human CD3E (HEK293, C-Fc) | Cytokines and Growth Factors |
| T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain | ||
| Recombinant human t cell surface glycoprotein CD3 Epsilon chain is produced by mammalian expression system, and the target gene encoding Asp23-Asp126 is expressed in the C-terminal human IgG1 Fc tag. Protein number: P07766. | ||
| M21663 | Recombinant Mouse DKK-1 (CHO) | Cytokines and Growth Factors |
| Dickkopf-1 | ||
| Dickkopf related protein 1 (DKK-1) is a chemokine that belongs to the DKK protein family, promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. ED50 < 6.0 µg/ml, measured in stimulation of alkaline phosphatase activity using CCl-226 cells. | ||
| M25318 | Anti-MERS-2E6 mAb | Anti-infection |
| MERS-2E6; MERS Antibody-2E6 | ||
| Anti-MERS-2E6 mAb (MERS-2E6; MERS Antibody-2E6), a human neutralizing antibody IgG1 (CHO expressed) that can compete for the binding of the virus Spike protein to the receptor (CD26), thereby inhibiting virus invasion into host cells. | ||
| M27782 | Veledimex | IL Receptor/Related |
| INXN-1001; RG-115932 | ||
| Veledimex (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system. Veledimex can be used to activate certain genes using the ecdysone receptor (EcR)-based inducible gene regulation system, the RheoSwitch Therapeutic System (RTS). Veledimex can cross blood-brain barrier (BBB) in both orthotopic GL-261 mice and cynomolgus monkeys. | ||
| M28295 | Ribocil | Antibiotic |
| Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3 μM. Target: in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 μM versus IC50 > 26 μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd ≥ 10,000 nM).[1] | ||
| M28748 | DETQ | Dopamine Receptor |
| DETQ is a selective, allosteric and orally active dopamine D1 receptor (Dopamine Receptor) potentiator. In HEK293 cells expressing the human D1 receptor, DETQ increases cAMP with an EC50 of 5.8 nM and a Kb of 26 nM. DETQ shows ~30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor. | ||
| M29134 | Azelaprag | Others |
| AMG 986 | ||
| Azelaprag (Example 263.0) is an apelin receptor agonist agent candidate. | ||
| M29481 | (E/Z)-E64FC26 | Apoptosis |
| (E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity. | ||
| M29593 | GLP-1 receptor agonist 9 | GLP Receptor |
| GLP-1 receptor agonist 9 is a GLP-1 receptor agonist, example 7, extracted from WO2020234726 A1. | ||
| M29759 | SZ-015268 | CDK |
| SZ-015268 is a CDK7 inhibitor with an IC50 of 23.56 nM. SZ-015268 has extremely significant anti-tumor advantages. SZ-015268 inhibits HCC70, OVCAR-3, HCT116 and HCC1806 cells proliferation with IC50s of 33, 80.56, 12.53, and 61.55 nM, respectively. | ||
| M30117 | GT 949 | EAAT |
| GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM. | ||
| M30775 | JNJ-26489112 | Calcium Channel |
| JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na+ channels and N-type Ca2+ channels, and is effective as a K+ channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC50=35 μM) and CA-I (18 μM). | ||
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