Free shipping on all orders over $ 500

Recombinant Human CD3E (HEK293, C-Fc)

Cat. No. M21572

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human CD3E (HEK293, C-Fc) Structure
Synonym:

T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain

Size Price Availability Quantity
10ug USD 190  USD190 In stock
50ug USD 400  USD400 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
  • Purity: >95%, Endotoxin<1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: Mammalian
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test less than 0.1 ng/µg (1 EU/µg)
Molecular weight: 38.7 KDa
Storage and stability; The freeze-dried protein should be stored at ≤-20℃ and stored stably for one year after receiving. The recombinant protein solution can be stored at 2-8℃ for 2-7 days. The recombinant samples were stable for 3 months at ≤-20°C.


Bioactivity: t cell surface glycoprotein CD3ε Chain is a single channel type I membrane protein. CD3ε contains one immunoglobulin-like domain and one ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on human chromosome 11. T cell receptor -CD3 complex (TCR/CD3 complex) is involved in T cell development and several intracellular signal transduction pathways. This complex is essential for t cell development and function and is one of the most complex transmembrane receptors. T cell receptor - cd3 complexes have 10 tyrosine-based cytoplasmic immune receptor activation primitives (ITAMs). The TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal transduction pathways.

Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Charlotte A James, et al. Nat Commun. CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

[2] Kamonlapat Supimon, et al. Sci Rep. Anti-mucin 1 chimeric antigen receptor T cells for adoptive T cell therapy of cholangiocarcinoma

[3] Martin Hart, et al. Cell Death Dis. miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling

[4] Jane Rasaiyaah, et al. JCI Insight. TCRαβ/CD3 disruption enables CD3-specific antileukemic T cell immunotherapy

[5] Sinem Firtina, et al. Immunogenetics. A novel pathogenic frameshift variant of CD3E gene in two T-B+ NK+ SCID patients from Turkey

Related Cytokines and Growth Factors Products
Recombinant Human GDF-15 Protein (HEK293 N-hFc)

Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily. GDF-15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.

Recombinant Human FGFR1 Protein (HEK293, C-His)

FGFR1, also known as CD331, is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain.

Recombinant Human FGFR2 Protein (HEK293, C-His)

FGFR2, also known as CD332, acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts.

Recombinant Mouse BMP-4 Protein (E. coli, C-His)

Bone Morphogenetic Protein-4 (BMP-4) is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP-4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog to establish a dorsal-ventral axis for the differentiation of later structures.

Recombinant Human Coagulation Factor X (HEK293, C-Fc)

Coagulation factor X, belongs to the peptidase S1 family. Coagulation factor X is initially synthesized in the liver. Coagulation factor X is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

  Catalog
Abmole Inhibitor Catalog




Keywords: Recombinant Human CD3E (HEK293, C-Fc), T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain supplier, Cytokines and Growth Factors, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.