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Recombinant Human CD3E (HEK293, C-Fc)

Cat. No. M21572

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human CD3E (HEK293, C-Fc) Structure
Synonym:

T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain

Size Price Availability Quantity
10ug USD 190  USD190 In stock
50ug USD 400  USD400 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin<1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: Mammalian
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test less than 0.1 ng/µg (1 EU/µg)
Molecular weight: 38.7 KDa
Storage and stability; The freeze-dried protein should be stored at ≤-20℃ and stored stably for one year after receiving. The recombinant protein solution can be stored at 2-8℃ for 2-7 days. The recombinant samples were stable for 3 months at ≤-20°C.


Bioactivity: t cell surface glycoprotein CD3ε Chain is a single channel type I membrane protein. CD3ε contains one immunoglobulin-like domain and one ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on human chromosome 11. T cell receptor -CD3 complex (TCR/CD3 complex) is involved in T cell development and several intracellular signal transduction pathways. This complex is essential for t cell development and function and is one of the most complex transmembrane receptors. T cell receptor - cd3 complexes have 10 tyrosine-based cytoplasmic immune receptor activation primitives (ITAMs). The TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal transduction pathways.

Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Charlotte A James, et al. Nat Commun. CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

[2] Kamonlapat Supimon, et al. Sci Rep. Anti-mucin 1 chimeric antigen receptor T cells for adoptive T cell therapy of cholangiocarcinoma

[3] Martin Hart, et al. Cell Death Dis. miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling

[4] Jane Rasaiyaah, et al. JCI Insight. TCRαβ/CD3 disruption enables CD3-specific antileukemic T cell immunotherapy

[5] Sinem Firtina, et al. Immunogenetics. A novel pathogenic frameshift variant of CD3E gene in two T-B+ NK+ SCID patients from Turkey

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Keywords: Recombinant Human CD3E (HEK293, C-Fc), T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain supplier, Cytokines and Growth Factors, inhibitors, activators

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