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Cafestol

Cat. No. M19411
Cafestol Structure
Size Price Availability Quantity
5mg USD 105  USD105 In stock
10mg USD 175  USD175 In stock
20mg USD 300  USD300 In stock
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Biological Activity

Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activatio䲧瓰Ỵ瓱㧀

Chemical Information
Molecular Weight 316.43
Formula C20H28O3
CAS Number 469-83-0
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ju-Chi Liu, et al. Evid Based Complement Alternat Med. Cafestol Inhibits High-Glucose-Induced Cardiac Fibrosis in Cardiac Fibroblasts and Type 1-Like Diabetic Rats

[2] Rob M van Dam, et al. N Engl J Med. Coffee, Caffeine, and Health

[3] Renalison Farias-Pereira, et al. Food Chem. Cafestol increases fat oxidation and energy expenditure in Caenorhabditis elegans via DAF-12-dependent pathway

[4] Yaqi Ren, et al. Int J Mol Sci. Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties

[5] Masood Sadiq Butt, et al. Crit Rev Food Sci Nutr. Coffee and its consumption: benefits and risks

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Keywords: Cafestol supplier, ERK, inhibitors, activators

 
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