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Veledimex

Cat. No. M27782

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Veledimex Structure
Synonym:

INXN-1001; RG-115932

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Quality Control & Documentation
Biological Activity

Veledimex (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system. Veledimex can be used to activate certain genes using the ecdysone receptor (EcR)-based inducible gene regulation system, the RheoSwitch Therapeutic System (RTS). Veledimex can cross blood-brain barrier (BBB) in both orthotopic GL-261 mice and cynomolgus monkeys.

Chemical Information
Molecular Weight 438.6
Formula C27H38N2O3
CAS Number 1093130-72-3
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] E Antonio Chiocca, et al. Neuro Oncol. Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial

[2] E Antonio Chiocca, et al. Sci Transl Med. Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

[3] Hongliang Cai, et al. Clin Pharmacol Drug Dev. Plasma Pharmacokinetics of Veledimex, a Small-Molecule Activator Ligand for a Proprietary Gene Therapy Promoter System, in Healthy Subjects

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  Catalog
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Keywords: Veledimex, INXN-1001; RG-115932 supplier, IL Receptor/Related, inhibitors, activators

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