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Roquinimex

Cat. No. M9710
Roquinimex Structure
Synonym:

LS2616; FCF89

Size Price Availability
25mg USD 300  USD300 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Roquinimex (LS2616; FCF89) is a quinoline-3-carboxamide with potential antineoplastic activity, which increases NK cell activity and macrophage cytotoxicity. Roquinimex at concentrations effective in vivo reduces the number of MBP-reactive TNF-alpha and increases MBP-reactive IL-10 and TGF-beta mRNA expressing MNC from MS blood when analysed in vitro.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 308.33
Formula C18H16N2O3
CAS Number 84088-42-6
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Zhi-Yong Xiao, et al. Life Sci. Roquinimex-mediated protection effect on the development of chronic graft-versus-host disease in mice is associated with induction of Th1 cytokine production and inhibition of proinflammatory cytokine production

[2] J Peltoniemi, et al. Clin Exp Immunol. Immunomodulation by roquinimex decreases the expression of IL-23 (p19) mRNA in the brains of herpes simplex virus type 1 infected BALB/c mice

[3] Q Liu, et al. Inflamm Res. Roquinimex inhibits dextran sodium sulfate-induced murine colitis

[4] W Z Tian, et al. Acta Neurol Scand. Roquinimex affects the balance between pro- and anti-inflammatory cytokines in vitro in multiple sclerosis

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Keywords: Roquinimex, LS2616; FCF89 supplier, TNF-alpha, inhibitors

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